Advanced biliary tract cancer (aBTC) comprises a heterogeneous group of rare malignancies with dismal prognosis. Given the scarcity of prospective evidence, the aim of this study was to derive clinically useful insights and prognostic factors from a large, real-world series of aBTC. Clinicopathologic variables and treatment outcomes were retrospectively collected involving 940 patients diagnosed with aBTC between 2001 and 2017, and treated with first-line chemotherapy (CT1) at 14 Italian medical oncology institutions. Median overall survival (OS) was 10.3 months (CI95% 9.5-11.1). CT1 with gemcitabine-Platinum salts doublets achieved OS of 11.7 months vs 7.5 with gemcitabine alone (HR 0.67, p < 0.001). However, a clear temporal trend towards improved OS could not be demonstrated. Radical surgery of recurrent disease achieved a relapse-free survival of 5.9 months. A substantial minority (44.5%) of patients were able to receive a second-line chemotherapy, which achieved a response rate of 7.6%, and disease control in 30% of patients with no significant differences between combination regimens and monotherapies. In a large retrospective series of real-world aBTC, outcomes of standard CT1 closely resembled those of the registrational trials. A limited set of easily retrievable independent prognostic factors was defined. Further research is needed on second-line regimens.

Filippi R., Leone F., Fornaro L., Aprile G., Casadei-Gardini A., Silvestris N., et al. (2021). Clinical insights and prognostic factors from an advanced biliary tract cancer case series: a real-world analysis. JOURNAL OF CHEMOTHERAPY, 1, 1-10 [10.1080/1120009X.2021.1953887].

Clinical insights and prognostic factors from an advanced biliary tract cancer case series: a real-world analysis

Palloni A.;Russano M.;Frega G.;Aglietta M.;Brandi G.
2021

Abstract

Advanced biliary tract cancer (aBTC) comprises a heterogeneous group of rare malignancies with dismal prognosis. Given the scarcity of prospective evidence, the aim of this study was to derive clinically useful insights and prognostic factors from a large, real-world series of aBTC. Clinicopathologic variables and treatment outcomes were retrospectively collected involving 940 patients diagnosed with aBTC between 2001 and 2017, and treated with first-line chemotherapy (CT1) at 14 Italian medical oncology institutions. Median overall survival (OS) was 10.3 months (CI95% 9.5-11.1). CT1 with gemcitabine-Platinum salts doublets achieved OS of 11.7 months vs 7.5 with gemcitabine alone (HR 0.67, p < 0.001). However, a clear temporal trend towards improved OS could not be demonstrated. Radical surgery of recurrent disease achieved a relapse-free survival of 5.9 months. A substantial minority (44.5%) of patients were able to receive a second-line chemotherapy, which achieved a response rate of 7.6%, and disease control in 30% of patients with no significant differences between combination regimens and monotherapies. In a large retrospective series of real-world aBTC, outcomes of standard CT1 closely resembled those of the registrational trials. A limited set of easily retrievable independent prognostic factors was defined. Further research is needed on second-line regimens.
2021
Filippi R., Leone F., Fornaro L., Aprile G., Casadei-Gardini A., Silvestris N., et al. (2021). Clinical insights and prognostic factors from an advanced biliary tract cancer case series: a real-world analysis. JOURNAL OF CHEMOTHERAPY, 1, 1-10 [10.1080/1120009X.2021.1953887].
Filippi R.; Leone F.; Fornaro L.; Aprile G.; Casadei-Gardini A.; Silvestris N.; Palloni A.; Satolli M.A.; Scartozzi M.; Russano M.; Lutrino S.E.; Lomb...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/876384
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