Sixty-two patients with ulcerative colitis localised to the distal sigmoid colon and rectum (<20 cm) entered the trial. Thirty-two were treated with 5-ASA 500 mg suppositories (Asacol) 3 times a day for 1 month while 30 received a placebo given in the same regime. Clinical, sigmoidoscopic and histological assessment was carried out before, after 15 days and after 1 month of treatment. At the end of the study 5-ASA suppositories showed significantly better results in all the parameters recorded than placebo (p<0.01). There were no unwanted effects related to the use of suppositories. This treatment should therefore be offered as a first choice for patients with distal rectosigmoiditis. © 1990 Springer-Verlag.

Campieri, M., Gionchetti, P., Belluzzi, A., Brignola, C., Tampieri, M., Iannone, P., et al. (1990). Topical treatment with 5-aminosalicylic in distal ulcerative colitis by using a new suppository preparation - A double-blind placebo controlled trial. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 5(2), 79-81 [10.1007/BF00298473].

Topical treatment with 5-aminosalicylic in distal ulcerative colitis by using a new suppository preparation - A double-blind placebo controlled trial

Campieri M.;Gionchetti P.;Belluzzi A.;Brignola C.;Iannone P.;Brunetti P.;Miglioli M.;Barbara L.
1990

Abstract

Sixty-two patients with ulcerative colitis localised to the distal sigmoid colon and rectum (<20 cm) entered the trial. Thirty-two were treated with 5-ASA 500 mg suppositories (Asacol) 3 times a day for 1 month while 30 received a placebo given in the same regime. Clinical, sigmoidoscopic and histological assessment was carried out before, after 15 days and after 1 month of treatment. At the end of the study 5-ASA suppositories showed significantly better results in all the parameters recorded than placebo (p<0.01). There were no unwanted effects related to the use of suppositories. This treatment should therefore be offered as a first choice for patients with distal rectosigmoiditis. © 1990 Springer-Verlag.
1990
Campieri, M., Gionchetti, P., Belluzzi, A., Brignola, C., Tampieri, M., Iannone, P., et al. (1990). Topical treatment with 5-aminosalicylic in distal ulcerative colitis by using a new suppository preparation - A double-blind placebo controlled trial. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 5(2), 79-81 [10.1007/BF00298473].
Campieri, M.; Gionchetti, P.; Belluzzi, A.; Brignola, C.; Tampieri, M.; Iannone, P.; Brunetti, P.; Miglioli, M.; Barbara, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/876276
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