Clinical experience with mesalazine enemas in the treatment of ulcerative colitis is reviewed. After rectal administration, plasma mesalazine levels remain low, and 15% of the administered dose is recovered in the urine. Enemas containing 2 and 4g of mesalazine have been shown to be effective, safe, and well tolerated by patients with mild and moderate ulcerative colitis. Patients who cannot tolerate sulfasalazine and patients who do not respond to other treatments have been successfully treated with mesalazine enemas. Suppositories of mesalazine are more suitable for patients with disease confined to the distal region of the colon, whereas mesalazine enemas should be used in patients with more extensive disease. Mesalazine enemas have also been used for maintenance therapy in ulcerative colitis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Campieri M., Gionchetti P., Belluzzi A., Brignola C., Tampieri M., Iannone P., et al. (1990). Role of rectal formulations: Enemas. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 25(172), 63-65 [10.3109/00365529009091914].
Role of rectal formulations: Enemas
Campieri M.;Gionchetti P.;Belluzzi A.;Brignola C.;Iannone P.;Miglioli M.;Barbara L.
1990
Abstract
Clinical experience with mesalazine enemas in the treatment of ulcerative colitis is reviewed. After rectal administration, plasma mesalazine levels remain low, and 15% of the administered dose is recovered in the urine. Enemas containing 2 and 4g of mesalazine have been shown to be effective, safe, and well tolerated by patients with mild and moderate ulcerative colitis. Patients who cannot tolerate sulfasalazine and patients who do not respond to other treatments have been successfully treated with mesalazine enemas. Suppositories of mesalazine are more suitable for patients with disease confined to the distal region of the colon, whereas mesalazine enemas should be used in patients with more extensive disease. Mesalazine enemas have also been used for maintenance therapy in ulcerative colitis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
