Human herpesvirus 7 (HHV-7) infection in histologically normal human tissues was investigated by immunohistochemical detection of the 85-kDa tegument phosphoprotein (pp85) encoded by the U14 gene. So far, two cell types were recognized as sites of HHV-7 infection in vivo: CD4+ T lymphocytes, believed to be the site of latent infection, and epithelial cells of salivary glands, the site of productive infection and vital shedding. Unexpectedly, cells expressing the HHV-7 structural antigen were detectable in lungs, skin, and mammary glands. Morphologically and phenotypically, they were distinct from lymphocytes. Liver, kidney, and tonsils were positive, although the number of HHV-7-positive cells was low. Large intestine, spleen, and brain were negative. Different from the current notion of the state of HHV-7 in humans, the results show that a variety of tissues harbor cells at a late stage of infection and suggest that HHV-7 causes a persistent rather than a true latent infection.

Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen / Kempf W.; Adams V.; Mirandola P.; Menotti L.; Di Luca D.; Wey N.; Muller B.; Campadelli-Fiume G.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - ELETTRONICO. - 178:3(1998), pp. 841-845. [10.1086/515339]

Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen

Menotti L.;Campadelli-Fiume G.
1998

Abstract

Human herpesvirus 7 (HHV-7) infection in histologically normal human tissues was investigated by immunohistochemical detection of the 85-kDa tegument phosphoprotein (pp85) encoded by the U14 gene. So far, two cell types were recognized as sites of HHV-7 infection in vivo: CD4+ T lymphocytes, believed to be the site of latent infection, and epithelial cells of salivary glands, the site of productive infection and vital shedding. Unexpectedly, cells expressing the HHV-7 structural antigen were detectable in lungs, skin, and mammary glands. Morphologically and phenotypically, they were distinct from lymphocytes. Liver, kidney, and tonsils were positive, although the number of HHV-7-positive cells was low. Large intestine, spleen, and brain were negative. Different from the current notion of the state of HHV-7 in humans, the results show that a variety of tissues harbor cells at a late stage of infection and suggest that HHV-7 causes a persistent rather than a true latent infection.
1998
Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen / Kempf W.; Adams V.; Mirandola P.; Menotti L.; Di Luca D.; Wey N.; Muller B.; Campadelli-Fiume G.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - ELETTRONICO. - 178:3(1998), pp. 841-845. [10.1086/515339]
Kempf W.; Adams V.; Mirandola P.; Menotti L.; Di Luca D.; Wey N.; Muller B.; Campadelli-Fiume G.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/873704
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 64
  • ???jsp.display-item.citation.isi??? ND
social impact