Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = –0.45 to –0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = –0.14 to –0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = –0.88 to –0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = –0.13 to –0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = –0.21 to –0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders.
Titolo: | Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings | |
Autore/i: | Velthorst E.; Mollon J.; Murray R. M.; de Haan L.; Germeys I. M.; Glahn D. C.; Arango C.; van der Ven E.; Di Forti M.; Bernardo M.; Guloksuz S.; Delespaul P.; Mezquida G.; Amoretti S.; Bobes J.; Saiz P. A.; Garcia-Portilla M. P.; Santos J. L.; Jimenez-Lopez E.; Sanjuan J.; Aguilar E. J.; Arrojo M.; Carracedo A.; Lopez G.; Gonzalez-Penas J.; Parellada M.; Atbasoglu C.; Saka M. C.; Ucok A.; Alptekin K.; Akdede B.; Binbay T.; Altinyazar V.; Ulas H.; Yalincetin B.; Gumus-Akay G.; Beyaz B. C.; Soygur H.; Cankurtaran E. S.; Kaymak S. U.; Maric N. P.; Mihaljevic M. M.; Petrovic S. A.; Mirjanic T.; Del-Ben C. M.; Ferraro L.; Gayer-Anderson C.; Jones P. B.; Jongsma H. E.; Kirkbride J. B.; La Cascia C.; Lasalvia A.; Tosato S.; Llorca P. -M.; Menezes P. R.; Morgan C.; Quattrone D.; Menchetti M.; Selten J. -P.; Szoke A.; Tarricone I.; Tortelli A.; McGuire P.; Valmaggia L.; Kempton M. J.; van der Gaag M.; Riecher-Rossler A.; Bressan R. A.; Barrantes-Vidal N.; Nelson B.; McGorry P.; Pantelis C.; Krebs M. -O.; Ruhrmann S.; Sachs G.; Rutten B. P. F.; van Os J.; Alizadeh B. Z.; van Amelsvoort T.; Bartels-Velthuis A. A.; Bruggeman R.; van Beveren N. J.; Luykx J. J.; Cahn W.; Simons C. J. P.; Kahn R. S.; Schirmbeck F.; van Winkel R.; Calem M.; Tognin S.; Modinos G.; Pisani S.; Kraan T. C.; van Dam D. S.; Burger N.; Amminger G. P.; Politis A.; Goodall J.; Borgwardt S.; Studerus E.; Gadelha A.; Brietzke E.; Asevedo G.; Asevedo E.; Zugman A.; Dominguez-Martinez T.; Monsonet M.; Cristobal-Narvaez P.; Racioppi A.; Kwapil T. R.; Kazes M.; Daban C.; Bourgin J.; Gay O.; Mam-Lam-Fook C.; Nordholm D.; Rander L.; Krakauer K.; Glenthoj L. B.; Glenthoj B.; Gebhard D.; Arnhold J.; Klosterkotter J.; Lasser I.; Winklbaur B.; Reichenberg A. | |
Autore/i Unibo: | ||
Anno: | 2021 | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41380-020-00969-z | |
Abstract: | Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = –0.45 to –0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = –0.14 to –0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = –0.88 to –0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = –0.13 to –0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = –0.21 to –0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders. | |
Data stato definitivo: | 2022-02-28T15:20:09Z | |
Appare nelle tipologie: | 1.01 Articolo in rivista |