Purpose: To investigate the prevalence, incidence and characteristics of bacterial infections and their impact on outcome in critically ill patients infected with COVID-19. Methods: We conducted a prospective observational study in eight Italian ICUs from February to May 2020; data were collected through an interactive electronic database. Kaplan–Meier analysis (limit product method) was used to identify the occurrence of infections and risk of acquisition. Results: During the study period 248 patients were recruited in the eight participating ICUs. Ninety (36.3%) patients developed at least one episode of secondary infection. An ICU length of stay between 7 and 14 days was characterized by a higher occurrence of infectious complications, with ventilator-associated pneumonia being the most frequent. At least one course of antibiotic therapy was given to 161 (64.9%) patients. Overall ICU and hospital mortality were 33.9% and 42.9%, respectively. Patients developing bacteremia had a higher risk of ICU mortality [45.9% vs. 31.6%, odds ratio 1.8 (95% CI 0.9–3.7), p = 0.069] and hospital mortality [56.8% vs. 40.3%, odds ratio 1.9 (95% CI 1.1–3.9), p = 0.04]. Conclusion: In critically ill patients infected with COVID-19 the incidence of bacterial infections is high and associated with worse outcomes. Regular microbiological surveillance and strict infection control measures are mandated.

Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study / De Santis V.; Corona A.; Vitale D.; Nencini C.; Potalivo A.; Prete A.; Zani G.; Malfatto A.; Tritapepe L.; Taddei S.; Locatelli A.; Sambri V.; Fusari M.; Singer M.. - In: INFECTION. - ISSN 0300-8126. - STAMPA. - 50:1(2022), pp. 139-148. [10.1007/s15010-021-01661-2]

Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study

Sambri V.;
2022

Abstract

Purpose: To investigate the prevalence, incidence and characteristics of bacterial infections and their impact on outcome in critically ill patients infected with COVID-19. Methods: We conducted a prospective observational study in eight Italian ICUs from February to May 2020; data were collected through an interactive electronic database. Kaplan–Meier analysis (limit product method) was used to identify the occurrence of infections and risk of acquisition. Results: During the study period 248 patients were recruited in the eight participating ICUs. Ninety (36.3%) patients developed at least one episode of secondary infection. An ICU length of stay between 7 and 14 days was characterized by a higher occurrence of infectious complications, with ventilator-associated pneumonia being the most frequent. At least one course of antibiotic therapy was given to 161 (64.9%) patients. Overall ICU and hospital mortality were 33.9% and 42.9%, respectively. Patients developing bacteremia had a higher risk of ICU mortality [45.9% vs. 31.6%, odds ratio 1.8 (95% CI 0.9–3.7), p = 0.069] and hospital mortality [56.8% vs. 40.3%, odds ratio 1.9 (95% CI 1.1–3.9), p = 0.04]. Conclusion: In critically ill patients infected with COVID-19 the incidence of bacterial infections is high and associated with worse outcomes. Regular microbiological surveillance and strict infection control measures are mandated.
2022
Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study / De Santis V.; Corona A.; Vitale D.; Nencini C.; Potalivo A.; Prete A.; Zani G.; Malfatto A.; Tritapepe L.; Taddei S.; Locatelli A.; Sambri V.; Fusari M.; Singer M.. - In: INFECTION. - ISSN 0300-8126. - STAMPA. - 50:1(2022), pp. 139-148. [10.1007/s15010-021-01661-2]
De Santis V.; Corona A.; Vitale D.; Nencini C.; Potalivo A.; Prete A.; Zani G.; Malfatto A.; Tritapepe L.; Taddei S.; Locatelli A.; Sambri V.; Fusari M.; Singer M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/872597
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