Objective: We aimed at carrying out a systematic review and meta-analysis of epidemiological studies on the association between occupational and non-occupational exposures to diesel exhaust and risk of non-Hodgkin lymphoma. Methods: We conducted a systematic search of the literature and identified 16 cohort studies and 7 case-control studies that analyzed non-Hodgkin lymphoma alone or combined with Hodgkin lymphoma or multiple myeloma, from which we extracted 29 independent risk estimates. We performed random-effects meta-analyses for ever-exposure to diesel exhaust, overall and after stratification for outcome and study design. Results: The meta-relative risk of non-Hodgkin lymphoma was 0.97 (95% confidence interval, 0.93-1.01; P-heterogeneity = 0.43). The meta-relative risk of results of cohort studies was 0.97 (95% confidence interval, 0.94-1.01) that of case-control studies was 1.00 (95% confidence interval, 0.84-1.17). Similar results were obtained when the meta-analysis was restricted to studies that analyzed only non-Hodgkin lymphoma. There was no indication of publication bias. Conclusion: Our meta-analysis provided no overall evidence of an increased risk of non-Hodgkin lymphoma in subjects exposed to diesel exhausted.
Titolo: | Diesel exhaust exposure and risk of non-Hodgkin lymphoma: a meta-analysis | |
Autore/i: | Vilardi, Valeria; Boffetta, Paolo | |
Autore/i Unibo: | ||
Anno: | 2021 | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/CEJ.0000000000000726 | |
Abstract: | Objective: We aimed at carrying out a systematic review and meta-analysis of epidemiological studies on the association between occupational and non-occupational exposures to diesel exhaust and risk of non-Hodgkin lymphoma. Methods: We conducted a systematic search of the literature and identified 16 cohort studies and 7 case-control studies that analyzed non-Hodgkin lymphoma alone or combined with Hodgkin lymphoma or multiple myeloma, from which we extracted 29 independent risk estimates. We performed random-effects meta-analyses for ever-exposure to diesel exhaust, overall and after stratification for outcome and study design. Results: The meta-relative risk of non-Hodgkin lymphoma was 0.97 (95% confidence interval, 0.93-1.01; P-heterogeneity = 0.43). The meta-relative risk of results of cohort studies was 0.97 (95% confidence interval, 0.94-1.01) that of case-control studies was 1.00 (95% confidence interval, 0.84-1.17). Similar results were obtained when the meta-analysis was restricted to studies that analyzed only non-Hodgkin lymphoma. There was no indication of publication bias. Conclusion: Our meta-analysis provided no overall evidence of an increased risk of non-Hodgkin lymphoma in subjects exposed to diesel exhausted. | |
Data stato definitivo: | 2022-02-26T12:02:37Z | |
Appare nelle tipologie: | 1.01 Articolo in rivista |