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EnglishN-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates, The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms, Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients ,vith cancers of the upper aerodigestive tract and 23 healthy individuals, After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers, The odds ratio for continuous units of total N-nitroso compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded.
| Titolo: | Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract | |
| Autore/i: | Airoldi L; Galli A; Mercato F; Vago F; Fanelli R; Negri E; LaVecchia C; Vierucci S | |
| Autore/i Unibo: | ||
| Anno: | 1997 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/00008469-199708000-00006 | |
| Abstract: | N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates, The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms, Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients ,vith cancers of the upper aerodigestive tract and 23 healthy individuals, After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers, The odds ratio for continuous units of total N-nitroso compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded. | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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