N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates, The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms, Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients ,vith cancers of the upper aerodigestive tract and 23 healthy individuals, After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers, The odds ratio for continuous units of total N-nitroso compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded.
Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract / Airoldi L; Galli A; Mercato F; Vago F; Fanelli R; Negri E; LaVecchia C; Vierucci S. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 6:4(1997), pp. 351-356. [10.1097/00008469-199708000-00006]
Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract
Negri E;
1997
Abstract
N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates, The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms, Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients ,vith cancers of the upper aerodigestive tract and 23 healthy individuals, After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers, The odds ratio for continuous units of total N-nitroso compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.