Objective: We investigated the relation between diabetes and the risk of prostate cancer, as epidemiological results are controversial. Methods: A hospital-based case-control study was conducted in Italy between 1991 and 2002. Cases were 1294 men, aged <75 years, with incident histologically confirmed prostate cancer, and controls were 1451 men, aged <75 years, admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. Results: No material association between diabetes and prostate cancer was observed, with a multivariate OR of 1.02 (95%CI 0.75-1.40). Prostate cancer was not related to time since diagnosis of diabetes (OR 0.82 and 0.97 for <5 and greater than or equal to15 years since diagnosis respectively). The OR were respectively 1.63 (95%CI 0.70-3.81) and 0.96 (95%CI 0.68-1.34) in men diagnosed with diabetes at age <45 or greater than or equal to45 years. The risk estimates were similar across strata of age at interview, body mass index and, among cases, of Gleason score. Conclusions: This study shows no material association between diabetes and prostate cancer risk. (C) 2004 Elsevier B.V. All rights reserved.
Tavani A, Gallus S, Bertuzzi A, Dal Maso L, Zucchetto A, Negri E, et al. (2005). Diabetes mellitus and the risk of prostate cancer in Italy. EUROPEAN UROLOGY, 47(3), 313-317 [10.1016/j.eururo.2004.10.027].
Diabetes mellitus and the risk of prostate cancer in Italy
Negri E;
2005
Abstract
Objective: We investigated the relation between diabetes and the risk of prostate cancer, as epidemiological results are controversial. Methods: A hospital-based case-control study was conducted in Italy between 1991 and 2002. Cases were 1294 men, aged <75 years, with incident histologically confirmed prostate cancer, and controls were 1451 men, aged <75 years, admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. Results: No material association between diabetes and prostate cancer was observed, with a multivariate OR of 1.02 (95%CI 0.75-1.40). Prostate cancer was not related to time since diagnosis of diabetes (OR 0.82 and 0.97 for <5 and greater than or equal to15 years since diagnosis respectively). The OR were respectively 1.63 (95%CI 0.70-3.81) and 0.96 (95%CI 0.68-1.34) in men diagnosed with diabetes at age <45 or greater than or equal to45 years. The risk estimates were similar across strata of age at interview, body mass index and, among cases, of Gleason score. Conclusions: This study shows no material association between diabetes and prostate cancer risk. (C) 2004 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
