Meal frequency and coffee intake in colon cancer

Several studies suggested that frequent eating may increase colon cancer risk. To further clarify this issue, a case-control study was carried out in sir areas of Italy on 1,225 incident cases <75 years of age with histologically confirmed colon cancer and 4,154 control subjects. The controls were hospitalized for acute nonneoplastic conditions unrelated to long-term dietary modifications. After allowance Sor education, physical activity, intake of vegetables, and major energy sources, there was a trend of increasing risk: with increasing eating frequency (adds ratio for greater than or equal to 4 vs. less than or equal to 2 daily meals = 1.24). Coffee intake, which was inversely associated with cancer risk, exerted a modification effect, with an adds ratio of 1.89 Sar frequent eaters who drank Sewer than two cups of coffee per day. Frequent eating increases, whereas high coffee intake decreases the excretion of bile acids, which are suspected to be carcinogenic to the colon. Thus, it is conceivable that frequent coffee intake may counter-balance the effect of frequent eating.