Tumor grading is a method to quantify the putative clinical aggressiveness of a neoplasm based on specific histological features. A good grading system should be simple, easy to use, reproducible, and accurately segregate tumors into those with low versus high risk. The aim of this review is to summarize the histological and, when available, cytological grading systems applied in veterinary pathology, providing information regarding their prognostic impact, reproducibility, usefulness, and shortcomings. Most of the grading schemes used in veterinary medicine are developed for common tumor entities. Grading systems exist for soft tissue sarcoma, osteosarcoma, multilobular tumor of bone, mast cell tumor, lymphoma, mammary carcinoma, pulmonary carcinoma, urothelial carcinoma, renal cell carcinoma, prostatic carcinoma, and central nervous system tumors. The prognostic relevance of many grading schemes has been demonstrated, but for some tumor types the usefulness of grading remains controversial. Furthermore, validation studies are available only for a minority of the grading systems. Contrasting data on the prognostic power of some grading systems, lack of detailed instructions in the materials and methods in some studies, and lack of data on reproducibility and validation studies are discussed for the relevant grading systems. Awareness of the limitations of grading is necessary for pathologists and oncologists to use these systems appropriately and to drive initiatives for their improvement.

Review of Histological Grading Systems in Veterinary Medicine / Avallone G.; Rasotto R.; Chambers J.K.; Miller A.D.; Behling-Kelly E.; Monti P.; Berlato D.; Valenti P.; Roccabianca P.. - In: VETERINARY PATHOLOGY. - ISSN 0300-9858. - STAMPA. - 58:5(2021), pp. 809-828. [10.1177/0300985821999831]

Review of Histological Grading Systems in Veterinary Medicine

Avallone G.
Primo
;
2021

Abstract

Tumor grading is a method to quantify the putative clinical aggressiveness of a neoplasm based on specific histological features. A good grading system should be simple, easy to use, reproducible, and accurately segregate tumors into those with low versus high risk. The aim of this review is to summarize the histological and, when available, cytological grading systems applied in veterinary pathology, providing information regarding their prognostic impact, reproducibility, usefulness, and shortcomings. Most of the grading schemes used in veterinary medicine are developed for common tumor entities. Grading systems exist for soft tissue sarcoma, osteosarcoma, multilobular tumor of bone, mast cell tumor, lymphoma, mammary carcinoma, pulmonary carcinoma, urothelial carcinoma, renal cell carcinoma, prostatic carcinoma, and central nervous system tumors. The prognostic relevance of many grading schemes has been demonstrated, but for some tumor types the usefulness of grading remains controversial. Furthermore, validation studies are available only for a minority of the grading systems. Contrasting data on the prognostic power of some grading systems, lack of detailed instructions in the materials and methods in some studies, and lack of data on reproducibility and validation studies are discussed for the relevant grading systems. Awareness of the limitations of grading is necessary for pathologists and oncologists to use these systems appropriately and to drive initiatives for their improvement.
2021
Review of Histological Grading Systems in Veterinary Medicine / Avallone G.; Rasotto R.; Chambers J.K.; Miller A.D.; Behling-Kelly E.; Monti P.; Berlato D.; Valenti P.; Roccabianca P.. - In: VETERINARY PATHOLOGY. - ISSN 0300-9858. - STAMPA. - 58:5(2021), pp. 809-828. [10.1177/0300985821999831]
Avallone G.; Rasotto R.; Chambers J.K.; Miller A.D.; Behling-Kelly E.; Monti P.; Berlato D.; Valenti P.; Roccabianca P.
File in questo prodotto:
File Dimensione Formato  
Review grading-post print.docx

accesso aperto

Tipo: Postprint
Licenza: Licenza per accesso libero gratuito
Dimensione 218.41 kB
Formato Microsoft Word XML
218.41 kB Microsoft Word XML Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/862159
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 36
  • ???jsp.display-item.citation.isi??? 30
social impact