Background and aims: We investigated the clinical impact of the newly defined metabolic-associated fatty liver disease (MAFLD) in patients undergoing hepatectomy for HCC (MAFLD-HCC) comparing the characteristics and outcomes of patients with MAFLD-HCC to viral- and alcoholic-related HCC (HCV-HCC, HBV-HCC, A-HCC). Methods: A retrospective analysis of patients included in the He.RC.O.Le.S. Group registry was performed. The characteristics, short- and long-term outcomes of 1315 patients included were compared according to the study group before and after an exact propensity score match (PSM). Results: Among the whole study population, 264 (20.1%) had MAFLD-HCC, 205 (15.6%) had HBV-HCC, 671 (51.0%) had HCV-HCC and 175 (13.3%) had A-HCC. MAFLD-HCC patients had higher BMI (p < 0.001), Charlson Comorbidities Index (p < 0.001), size of tumour (p < 0.001), and presence of cirrhosis (p < 0.001). After PSM, the 90-day mortality and severe morbidity rates were 5.9% and 7.1% in MAFLD-HCC, 2.3% and 7.1% in HBV-HCC, 3.5% and 11.7% in HCV-HCC, and 1.2% and 8.2% in A-HCC (p = 0.061 and p = 0.447, respectively). The 5-year OS and RFS rates were 54.4% and 37.1% in MAFLD-HCC, 64.9% and 32.2% in HBV-HCC, 53.4% and 24.7% in HCV-HCC and 62.0% and 37.8% in A-HCC (p = 0.345 and p = 0.389, respectively). Cirrhosis, multiple tumours, size and satellitosis seems to be the independent predictors of OS. Conclusion: Hepatectomy for MAFLD-HCC seems to have a higher but acceptable operative risk. However, long-term outcomes seems to be related to clinical and pathological factors rather than aetiological risk factors.

Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC / Conci S.; Cipriani F.; Donadon M.; Marchitelli I.; Ardito F.; Famularo S.; Perri P.; Iaria M.; Ansaloni L.; Zanello M.; La Barba G.; Patauner S.; Pinotti E.; Molfino S.; Germani P.; Romano M.; Sciannamea I.; Ferrari C.; Manzoni A.; Troci A.; Fumagalli L.; Delvecchio A.; Floridi A.; Memeo R.; Chiarelli M.; Crespi M.; Zimmitti G.; Griseri G.; Antonucci A.; Zanus G.; Tarchi P.; Baiocchi G.L.; Zago M.; Frena A.; Ercolani G.; Jovine E.; Maestri M.; Valle R.D.; Grazi G.L.; Romano F.; Giuliante F.; Torzilli G.; Aldrighetti L.; Ruzzenente A.. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - ELETTRONICO. - 48:1(2022), pp. 103-112. [10.1016/j.ejso.2021.07.015]

Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC

Zanello M.;La Barba G.;Fumagalli L.;Chiarelli M.;Ercolani G.;Jovine E.;
2022

Abstract

Background and aims: We investigated the clinical impact of the newly defined metabolic-associated fatty liver disease (MAFLD) in patients undergoing hepatectomy for HCC (MAFLD-HCC) comparing the characteristics and outcomes of patients with MAFLD-HCC to viral- and alcoholic-related HCC (HCV-HCC, HBV-HCC, A-HCC). Methods: A retrospective analysis of patients included in the He.RC.O.Le.S. Group registry was performed. The characteristics, short- and long-term outcomes of 1315 patients included were compared according to the study group before and after an exact propensity score match (PSM). Results: Among the whole study population, 264 (20.1%) had MAFLD-HCC, 205 (15.6%) had HBV-HCC, 671 (51.0%) had HCV-HCC and 175 (13.3%) had A-HCC. MAFLD-HCC patients had higher BMI (p < 0.001), Charlson Comorbidities Index (p < 0.001), size of tumour (p < 0.001), and presence of cirrhosis (p < 0.001). After PSM, the 90-day mortality and severe morbidity rates were 5.9% and 7.1% in MAFLD-HCC, 2.3% and 7.1% in HBV-HCC, 3.5% and 11.7% in HCV-HCC, and 1.2% and 8.2% in A-HCC (p = 0.061 and p = 0.447, respectively). The 5-year OS and RFS rates were 54.4% and 37.1% in MAFLD-HCC, 64.9% and 32.2% in HBV-HCC, 53.4% and 24.7% in HCV-HCC and 62.0% and 37.8% in A-HCC (p = 0.345 and p = 0.389, respectively). Cirrhosis, multiple tumours, size and satellitosis seems to be the independent predictors of OS. Conclusion: Hepatectomy for MAFLD-HCC seems to have a higher but acceptable operative risk. However, long-term outcomes seems to be related to clinical and pathological factors rather than aetiological risk factors.
2022
Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC / Conci S.; Cipriani F.; Donadon M.; Marchitelli I.; Ardito F.; Famularo S.; Perri P.; Iaria M.; Ansaloni L.; Zanello M.; La Barba G.; Patauner S.; Pinotti E.; Molfino S.; Germani P.; Romano M.; Sciannamea I.; Ferrari C.; Manzoni A.; Troci A.; Fumagalli L.; Delvecchio A.; Floridi A.; Memeo R.; Chiarelli M.; Crespi M.; Zimmitti G.; Griseri G.; Antonucci A.; Zanus G.; Tarchi P.; Baiocchi G.L.; Zago M.; Frena A.; Ercolani G.; Jovine E.; Maestri M.; Valle R.D.; Grazi G.L.; Romano F.; Giuliante F.; Torzilli G.; Aldrighetti L.; Ruzzenente A.. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - ELETTRONICO. - 48:1(2022), pp. 103-112. [10.1016/j.ejso.2021.07.015]
Conci S.; Cipriani F.; Donadon M.; Marchitelli I.; Ardito F.; Famularo S.; Perri P.; Iaria M.; Ansaloni L.; Zanello M.; La Barba G.; Patauner S.; Pinotti E.; Molfino S.; Germani P.; Romano M.; Sciannamea I.; Ferrari C.; Manzoni A.; Troci A.; Fumagalli L.; Delvecchio A.; Floridi A.; Memeo R.; Chiarelli M.; Crespi M.; Zimmitti G.; Griseri G.; Antonucci A.; Zanus G.; Tarchi P.; Baiocchi G.L.; Zago M.; Frena A.; Ercolani G.; Jovine E.; Maestri M.; Valle R.D.; Grazi G.L.; Romano F.; Giuliante F.; Torzilli G.; Aldrighetti L.; Ruzzenente A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/861666
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