Procto-colectomy with an ileal pouch anal anastomosis is the procedure of choice for ulcerative colitis patients that require colectomy. Pouchitis is a non-specific inflammation of the ileal reservoir, and the most common, inflammatory and long-term, complication after pouch surgery for ulcerative colitis. The aetiology is still unknown, but many risk factors have been individuated. Pouchitis can be classified based on aetiology, duration, clinical course, and response to antibiotic therapy. Accurate diagnosis and classification is the key factor for an adequate management, and exclusion of secondary causes of pouchitis is pivotal. Most of the patients consistently respond to antibiotic therapy, but management of the subgroup of patients with chronic-antibiotic-resistant-pouchitis is still challenging, being this entity one of the major causes of pouch failure.

Gionchetti P., Calabrese C., Laureti S., Poggioli G., Rizzello F. (2021). Pouchitis: Clinical features, diagnosis, and treatment. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 14, 3871-3879 [10.2147/IJGM.S306039].

Pouchitis: Clinical features, diagnosis, and treatment

Gionchetti P.;Calabrese C.;Laureti S.;Poggioli G.;Rizzello F.
2021

Abstract

Procto-colectomy with an ileal pouch anal anastomosis is the procedure of choice for ulcerative colitis patients that require colectomy. Pouchitis is a non-specific inflammation of the ileal reservoir, and the most common, inflammatory and long-term, complication after pouch surgery for ulcerative colitis. The aetiology is still unknown, but many risk factors have been individuated. Pouchitis can be classified based on aetiology, duration, clinical course, and response to antibiotic therapy. Accurate diagnosis and classification is the key factor for an adequate management, and exclusion of secondary causes of pouchitis is pivotal. Most of the patients consistently respond to antibiotic therapy, but management of the subgroup of patients with chronic-antibiotic-resistant-pouchitis is still challenging, being this entity one of the major causes of pouch failure.
2021
Gionchetti P., Calabrese C., Laureti S., Poggioli G., Rizzello F. (2021). Pouchitis: Clinical features, diagnosis, and treatment. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 14, 3871-3879 [10.2147/IJGM.S306039].
Gionchetti P.; Calabrese C.; Laureti S.; Poggioli G.; Rizzello F.
File in questo prodotto:
File Dimensione Formato  
IJGM-306039-pouchitis--clinical-features--diagnosis--and-treatment.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale (CCBYNC)
Dimensione 371.84 kB
Formato Adobe PDF
371.84 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/860905
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 7
social impact