Purpose: To evaluate associations between CD4/CD8 ratio and pregnancy outcomes in women with HIV. Methods: We evaluated, in a national study of pregnant women with HIV receiving antiretroviral treatment (ART), values of CD4/CD8 ratio at entry in pregnancy, changes between first and third trimester, and possible associations with preterm delivery, low birthweight, and HIV-RNA < 50 copies/ml at third trimester in univariate and multivariate analyses. Results: Among 934 women, 536 (57.4%) were already on ART at conception. CD4/CD8 ratio (baseline value 0.570) increased significantly between the first and third trimesters, particularly in women who started ART in pregnancy (+ 0.163, vs. + 0.036 in women already on treatment). The rate of CD4/CD8 ratio normalization, defined by achieving a ratio ≥ 1 at the third trimester, was 13.2%. In multivariable analyses, women who entered pregnancy with a CD4/CD8 ratio < 0.3, compared to women with ratio ≥ 1, were almost four-times less likely to have third-trimester HIV-RNA < 50 copies/ml (AOR 0.258, 95%CI 0.111–0.601), and more than twice as likely to have preterm delivery (AOR 2.379, 95%CI 1.082–5.232). For preterm delivery, also a baseline CD4/CD8 ratio between 0.3 and 0.45 was significantly associated with an increased risk (AOR: 3.415, 95%CI 1.690–6.900). Conclusion: We described for the first time independent associations of low CD4/CD8 ratio with preterm delivery and HIV-RNA suppression.

CD4/CD8 ratio in pregnant women with HIV and its association with pregnancy outcome: data from a national study in Italy

Guerra B.;Cervi F.;Simonazzi G.;Margarito E.;Capretti M. G.;Marsico C.;Faldella G.;
2021

Abstract

Purpose: To evaluate associations between CD4/CD8 ratio and pregnancy outcomes in women with HIV. Methods: We evaluated, in a national study of pregnant women with HIV receiving antiretroviral treatment (ART), values of CD4/CD8 ratio at entry in pregnancy, changes between first and third trimester, and possible associations with preterm delivery, low birthweight, and HIV-RNA < 50 copies/ml at third trimester in univariate and multivariate analyses. Results: Among 934 women, 536 (57.4%) were already on ART at conception. CD4/CD8 ratio (baseline value 0.570) increased significantly between the first and third trimesters, particularly in women who started ART in pregnancy (+ 0.163, vs. + 0.036 in women already on treatment). The rate of CD4/CD8 ratio normalization, defined by achieving a ratio ≥ 1 at the third trimester, was 13.2%. In multivariable analyses, women who entered pregnancy with a CD4/CD8 ratio < 0.3, compared to women with ratio ≥ 1, were almost four-times less likely to have third-trimester HIV-RNA < 50 copies/ml (AOR 0.258, 95%CI 0.111–0.601), and more than twice as likely to have preterm delivery (AOR 2.379, 95%CI 1.082–5.232). For preterm delivery, also a baseline CD4/CD8 ratio between 0.3 and 0.45 was significantly associated with an increased risk (AOR: 3.415, 95%CI 1.690–6.900). Conclusion: We described for the first time independent associations of low CD4/CD8 ratio with preterm delivery and HIV-RNA suppression.
2021
Floridia M.; Pinnetti C.; Masuelli G.; Spinillo A.; Savasi V.M.; Liuzzi G.; Degli Antoni A.M.; Sansone M.; Guaraldi G.; Dalzero S.; Maso G.; Francisci D.; Sterrantino G.; Ravizza M.; Tamburrini E.; Floridia M.; Ravizza M.; Tamburrini E.; Ravizza M.; Tamburrini E.; Di Lorenzo F.; Sterrantino G.; Meli M.; Campolmi I.; Vichi F.; Del Pin B.; Marocco R.; Mastroianni C.; Mercurio V.S.; Zanaboni D.; Guaraldi G.; Nardini G.; Stentarelli C.; Beghetto B.; Degli Antoni A.M.; Molinari A.; Crisalli M.P.; Donisi A.; Ruggieri A.; Piepoli M.; Cerri V.; Zuccotti G.; Giacomet V.; Paradiso L.; Forlanini F.; Longoni E.; Placido G.; Milini P.; Savalli F.; Sabbatini F.; Papalini C.; Bernini L.; Grossi P.; Rizzi L.; Portelli V.; Maso G.; Bernardon M.; Bussolaro S.; Della Pieta I.; Sorz A.; Meloni A.; Chiodo A.; Dedoni M.; Ortu F.; Piano P.; Citernesi A.; Bordoni Vicini I.; Luzi K.; Roccio M.; Vimercati A.; Calabretti D.; Gigante S.; Guerra B.; Cervi F.; Simonazzi G.; Margarito E.; Capretti M.G.; Marsico C.; Faldella G.; Sansone M.; Martinelli P.; Agangi A.; Capone A.; Maruotti G.M.; Tibaldi C.; Trentini L.; Todros T.; Masuelli G.; Frisina V.; Savasi V.; Cardellicchio E.; Giaquinto C.; Fiscon M.; Rubino E.; Franceschetti L.; Badolato R.; Forleo M.A.; Tassis B.; Ruggiero M.; Genovese O.; Cafforio C.; Pinnetti C.; Casadei A.M.; Cavaliere A.F.; Cellini M.; Marconi A.M.; Dalzero S.; Ierardi M.; Simonetti S.C.; Alfieri N.; Agrati S.; Polizzi C.; Mattei A.; Pirillo M.F.; Amici R.; Galluzzo C.M.; Donnini S.; Baroncelli S.; Floridia M.; Cerioli A.; De Martino M.; Parazzini F.; Tamburrini E.; Vella S.; Martinelli P.; Ravizza M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/858625
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