Background: Perioperative management of pheochromocytoma (PCC) remains under debate. Methods: A bicentric retrospective study was conducted, including all patients who underwent laparoscopic adrenalectomy for PCC from 2000 to 2017. Patients were divided into two groups: Group 1 treated with alpha‐blockade, and Group 2, without alfa‐blockers. The primary end point was the major complication rate. The secondary end points were: the need for advanced intraoperative hemostasis, the admission to the intensive care unit (ICU), the length of stay (LOS), systolic (SBP), and diastolic blood pressure (DBP). Univariate and multivariate analysis was conducted. A p‐value < 0.05 was considered statistically significant. Results: Major postoperative complications were similar (p = 0.49). Advanced hemostatic agents were 44.9% in Group 1 and 100% in Group 2 (p < 0.001). In Group 2, no patients were admitted to the ICU, while only 73.5% of Group 1 (p < 0.001) were admitted. The median length of stay was larger in Group 1 than in Group 2 (p = 0.026). At the induction, SBP was 130 mmHg in Group 1, and 115 mmHg (p < 0.001). The pre‐surgery treatment was the only almost statistically significant variable at the multivariate analysis of DBP at the end of surgery. Conclusion: The preoperative use of alfa‐blockers should be considered not a dogma in PCC.

Buscemi S., Di Buono G., D'andrea R., Ricci C., Alberici L., Querci L., et al. (2021). Perioperative management of pheochromocytoma: From a dogmatic to a tailored approach. JOURNAL OF CLINICAL MEDICINE, 10(16), 3759-3765 [10.3390/jcm10163759].

Perioperative management of pheochromocytoma: From a dogmatic to a tailored approach

Ricci C.
;
Querci L.;
2021

Abstract

Background: Perioperative management of pheochromocytoma (PCC) remains under debate. Methods: A bicentric retrospective study was conducted, including all patients who underwent laparoscopic adrenalectomy for PCC from 2000 to 2017. Patients were divided into two groups: Group 1 treated with alpha‐blockade, and Group 2, without alfa‐blockers. The primary end point was the major complication rate. The secondary end points were: the need for advanced intraoperative hemostasis, the admission to the intensive care unit (ICU), the length of stay (LOS), systolic (SBP), and diastolic blood pressure (DBP). Univariate and multivariate analysis was conducted. A p‐value < 0.05 was considered statistically significant. Results: Major postoperative complications were similar (p = 0.49). Advanced hemostatic agents were 44.9% in Group 1 and 100% in Group 2 (p < 0.001). In Group 2, no patients were admitted to the ICU, while only 73.5% of Group 1 (p < 0.001) were admitted. The median length of stay was larger in Group 1 than in Group 2 (p = 0.026). At the induction, SBP was 130 mmHg in Group 1, and 115 mmHg (p < 0.001). The pre‐surgery treatment was the only almost statistically significant variable at the multivariate analysis of DBP at the end of surgery. Conclusion: The preoperative use of alfa‐blockers should be considered not a dogma in PCC.
2021
Buscemi S., Di Buono G., D'andrea R., Ricci C., Alberici L., Querci L., et al. (2021). Perioperative management of pheochromocytoma: From a dogmatic to a tailored approach. JOURNAL OF CLINICAL MEDICINE, 10(16), 3759-3765 [10.3390/jcm10163759].
Buscemi S.; Di Buono G.; D'andrea R.; Ricci C.; Alberici L.; Querci L.; Selva S.; Minni F.; Citarrella R.; Romano G.; Agrusa A.
File in questo prodotto:
File Dimensione Formato  
Buscemi_2021.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per accesso libero gratuito
Dimensione 210.56 kB
Formato Adobe PDF
210.56 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/857883
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 3
social impact