MicroFE models of porcine vertebrae with induced bone focal lesions: Validation of predicted displacements with digital volume correlation

The evaluation of the local mechanical behavior as a result of metastatic lesions is fundamental for the characterization of the mechanical competence of metastatic vertebrae. Micro finite element (microFE) models have the potential of addressing this challenge through laboratory studies but their predictions of local deformation due to the complexity of the bone structure compromized by the lesion must be validated against experiments. In this study, the displacements predicted by homogeneous, linear and isotropic microFE models of vertebrae were validated against experimental Digital Volume Correlation (DVC) measurements. Porcine spine segments, with and without mechanically induced focal lesions, were tested in compression within a micro computed tomography (microCT) scanner. The displacement within the bone were measured with an optimized global DVC approach (BoneDVC). MicroFE models of the intact and lesioned vertebrae, including or excluding the growth plates, were developed from the microCT images. The microFE and DVC boundary conditions were matched. The displacements measured by the DVC and predicted by the microFE along each Cartesian direction were compared. The results showed an excellent agreement between the measured and predicted displacements, both for intact and metastatic vertebrae, in the middle of the vertebra, in those cases where the structure was not loaded beyond yield (0.69 < R2 < 1.00). Models with growth plates showed the worst correlations (0.02 < R2 < 0.99), while a clear improvement was observed if the growth plates were excluded (0.56 < R2 < 1.00). In conclusion, these simplified models can predict complex displacement fields in the elastic regime with high reliability, more complex non-linear models should be implemented to predict regions with high deformation, when the bone is loaded beyond yield.