In this paper we address the problem of tuning parameters of a biological model, in particular a simulator of stochastic processes. The task is defined as an optimisation problem over the parameter space in which the objective function to be minimised is the distance between the output of the simulator and a target one. We tackle the problem with a metaheuristic algorithm for continuous variables, Particle swarm optimisation, and show the effectiveness of the method in a prominent case-study, namely the mitogen-activated protein kinase cascade.
Parameter tuning of a stochastic biological simulator by metaheuristics / S. Montagna; A. Roli. - STAMPA. - 5883:(2009), pp. 466-475. (Intervento presentato al convegno XI International Conference of the Italian Association for Artificial Intelligence tenutosi a Reggio Emilia (Italy) nel December 9-12, 2009) [10.1007/978-3-642-10291-2_47].
Parameter tuning of a stochastic biological simulator by metaheuristics
MONTAGNA, SARA;ROLI, ANDREA
2009
Abstract
In this paper we address the problem of tuning parameters of a biological model, in particular a simulator of stochastic processes. The task is defined as an optimisation problem over the parameter space in which the objective function to be minimised is the distance between the output of the simulator and a target one. We tackle the problem with a metaheuristic algorithm for continuous variables, Particle swarm optimisation, and show the effectiveness of the method in a prominent case-study, namely the mitogen-activated protein kinase cascade.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
