We use NMR directly in live human cells to describe the complete post-translational maturation process of human superoxide dismutase 1 (SOD1). We follow, at atomic resolution, zinc binding, homodimer formation and copper uptake, and discover that copper chaperone for SOD1 oxidizes the SOD1 intrasubunit disulfide bond through both copper-dependent and copper-independent mechanisms.

BANCI, L., BARBIERI, L., BERTINI, I., LUCHINAT, E., SECCI, E., Zhao Y, et al. (2013). Atomic-resolution monitoring of protein maturation in live human cells by NMR. NATURE CHEMICAL BIOLOGY, 9, 297-299 [10.1038/NCHEMBIO.1202].

Atomic-resolution monitoring of protein maturation in live human cells by NMR

LUCHINAT, ENRICO;
2013

Abstract

We use NMR directly in live human cells to describe the complete post-translational maturation process of human superoxide dismutase 1 (SOD1). We follow, at atomic resolution, zinc binding, homodimer formation and copper uptake, and discover that copper chaperone for SOD1 oxidizes the SOD1 intrasubunit disulfide bond through both copper-dependent and copper-independent mechanisms.
2013
BANCI, L., BARBIERI, L., BERTINI, I., LUCHINAT, E., SECCI, E., Zhao Y, et al. (2013). Atomic-resolution monitoring of protein maturation in live human cells by NMR. NATURE CHEMICAL BIOLOGY, 9, 297-299 [10.1038/NCHEMBIO.1202].
BANCI, LUCIA; BARBIERI, LETIZIA; BERTINI, IVANO; LUCHINAT, ENRICO; SECCI, ERICA; Zhao Y; Aricescu AR
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/856273
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