Since more than ten years our group has been actively involved in research on spray congealing, one of the useful methods for the preparation of solid lipid microparticles. Till now this technology has been successfully employed for producing microspheres loaded with numerous conventional small molecular weight drugs, but its application to phytochemicals or proteins has been rarely reported. This research aimed to evaluate the suitability of spray congealing for the production of delivery systems loaded with phytochemicals or proteins. Gelucire 50/13 microparticles loaded with sylimarin (a low water soluble Sylibum marianum extract) both pure or in a activated status (mechanochemical activation with croscarmelose sodium) were prepared and characterised (particle size, morphology, drug loading, solubility, solubilization kinetics, DSC, FT-IR and XRD analysis). The results showed that spherical microspheres having encapsulation efficienty > 90% and a significant improvement of sylimarin solubilization kinetic were obtained. The in vivo absorbtion studies on rats showed remarkable enhancement of the oral bioavailability of the sylimarin-activated loaded systems compared to commercial product.Recently the suitability of spray congealing for the microencapsulation of a model protein (bovine serum albumin, BSA) using lipid carriers (Precirol ATO 5, Dynasan 114 and 118) has also been evaluated. Preliminary results suggested that the technique enabled the production of BSA loaded systems without affecting the BSA stability
N. Passerini, B. Albertini, B. Perissutti, M. Di Sabatino, V.L Kett , D. Voinovich, et al. (2009). Recent application of the spray congealing technology: production of microparticles loaded with phytochemicals or protein. CAGLIARI : s.n.
Recent application of the spray congealing technology: production of microparticles loaded with phytochemicals or protein
PASSERINI, NADIA;ALBERTINI, BEATRICE;DI SABATINO, MARCELLO;RODRIGUEZ, LORENZO
2009
Abstract
Since more than ten years our group has been actively involved in research on spray congealing, one of the useful methods for the preparation of solid lipid microparticles. Till now this technology has been successfully employed for producing microspheres loaded with numerous conventional small molecular weight drugs, but its application to phytochemicals or proteins has been rarely reported. This research aimed to evaluate the suitability of spray congealing for the production of delivery systems loaded with phytochemicals or proteins. Gelucire 50/13 microparticles loaded with sylimarin (a low water soluble Sylibum marianum extract) both pure or in a activated status (mechanochemical activation with croscarmelose sodium) were prepared and characterised (particle size, morphology, drug loading, solubility, solubilization kinetics, DSC, FT-IR and XRD analysis). The results showed that spherical microspheres having encapsulation efficienty > 90% and a significant improvement of sylimarin solubilization kinetic were obtained. The in vivo absorbtion studies on rats showed remarkable enhancement of the oral bioavailability of the sylimarin-activated loaded systems compared to commercial product.Recently the suitability of spray congealing for the microencapsulation of a model protein (bovine serum albumin, BSA) using lipid carriers (Precirol ATO 5, Dynasan 114 and 118) has also been evaluated. Preliminary results suggested that the technique enabled the production of BSA loaded systems without affecting the BSA stabilityI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
