A combinatorial screening revealed the peptide H-His-d-Leu-d-Asp-NH2(1) as an additive for the generation of monodisperse, water-soluble palladium nanoparticles with average diameters of 3 nm and stabilities of over 9 months. The tripeptide proved to be also applicable for the size-controlled formation of other noble-metal nanoparticles (Pt and Au). Studies with close analogues of peptide 1 revealed a specific role of each of the three amino acids for the formation and stabilization of the nanoparticles. These data combined with microscopic and spectroscopic analyses provided insight into the structure of the self-assembled peptidic monolayer around the metal core. The results open interesting prospects for the development of functionalized metal nanoparticles.
Stefano Corra, Lewandowska U., Benetti E.M., Wennemers H. (2016). Size-Controlled Formation of Noble-Metal Nanoparticles in Aqueous Solution with a Thiol-Free Tripeptide. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 55(30), 8542-8545 [10.1002/anie.201510337].
Size-Controlled Formation of Noble-Metal Nanoparticles in Aqueous Solution with a Thiol-Free Tripeptide
Stefano Corra;
2016
Abstract
A combinatorial screening revealed the peptide H-His-d-Leu-d-Asp-NH2(1) as an additive for the generation of monodisperse, water-soluble palladium nanoparticles with average diameters of 3 nm and stabilities of over 9 months. The tripeptide proved to be also applicable for the size-controlled formation of other noble-metal nanoparticles (Pt and Au). Studies with close analogues of peptide 1 revealed a specific role of each of the three amino acids for the formation and stabilization of the nanoparticles. These data combined with microscopic and spectroscopic analyses provided insight into the structure of the self-assembled peptidic monolayer around the metal core. The results open interesting prospects for the development of functionalized metal nanoparticles.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.