The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.
Autoantibodies to speckled protein family in primary biliary cholangitis / Granito A.; Muratori L.; Tovoli F.; Muratori P.. - In: ALLERGY, ASTHMA, AND CLINICAL IMMUNOLOGY. - ISSN 1710-1484. - STAMPA. - 17:1(2021), pp. 35.35-35.38. [10.1186/s13223-021-00539-0]
Autoantibodies to speckled protein family in primary biliary cholangitis
Granito A.
;Muratori L.;Tovoli F.;Muratori P.
2021
Abstract
The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.File | Dimensione | Formato | |
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