STUDY DESIGN: To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by (18)F-Fluorodeoxyglucose ((18)F-FDG)-positron emission tomography (PET). METHODS: We prospectively enrolled 20 PLWH and 20 uninfected people with no known cardiovascular disease and at least 3 traditional cardiovascular risk factors. All patients underwent (18)F-FDG-PET/computed tomography (CT) of the thorax and neck. Biomarkers linked to inflammation and atherosclerosis were also determined. The primary outcome was AI in ascending aorta (AA) measured as mean maximum target-to-background ratio (TBR(max)). The independent relationships between HIV status and both TBR(max) and biomarkers were evaluated by multivariable linear regression adjusted for body mass index, creatinine, statin therapy, and atherosclerotic cardiovascular 10-year estimated risk (ASCVD). RESULTS: Unadjusted mean TBR(max) in AA was slightly higher but not statistically different (P = .18) in PLWH (2.07; IQR 1.97, 2.32]) than uninfected people (2.01; IQR 1.85, 2.16]). On multivariable analysis, PLWH had an independent risk of increased mean log-TBR(max) in AA (coef = 0.12; 95%CI 0.01,0.22; P = .032). HIV infection was independently associated with higher values of interleukin-10 (coef = 0.83; 95%CI 0.34, 1.32; P = .001), interferon-γ (coef. = 0.90; 95%CI 0.32, 1.47; P = .003), and vascular cell adhesion molecule-1 (VCAM-1) (coef. = 0.75; 95%CI: 0.42, 1.08, P < .001). CONCLUSIONS: In patients with high cardiovascular risk, HIV status was an independent predictor of increased TBR(max) in AA. PLWH also had an increased independent risk of IFN-γ, IL-10, and VCAM-1 levels.

Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people

Taglieri, Nevio;Bonfiglioli, Rachele;Bon, Isabella;Malosso, Pietro;Bruno, Matteo;Granozzi, Bianca;Palmerini, Tullio;Ghetti, Gabriele;Tamburello, Martina;Bruno, Antonio Giulio;Saia, Francesco;Calza, Leonardo;Fanti, Stefano;Re, Maria Carla;Galié, Nazzareno
2021

Abstract

STUDY DESIGN: To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by (18)F-Fluorodeoxyglucose ((18)F-FDG)-positron emission tomography (PET). METHODS: We prospectively enrolled 20 PLWH and 20 uninfected people with no known cardiovascular disease and at least 3 traditional cardiovascular risk factors. All patients underwent (18)F-FDG-PET/computed tomography (CT) of the thorax and neck. Biomarkers linked to inflammation and atherosclerosis were also determined. The primary outcome was AI in ascending aorta (AA) measured as mean maximum target-to-background ratio (TBR(max)). The independent relationships between HIV status and both TBR(max) and biomarkers were evaluated by multivariable linear regression adjusted for body mass index, creatinine, statin therapy, and atherosclerotic cardiovascular 10-year estimated risk (ASCVD). RESULTS: Unadjusted mean TBR(max) in AA was slightly higher but not statistically different (P = .18) in PLWH (2.07; IQR 1.97, 2.32]) than uninfected people (2.01; IQR 1.85, 2.16]). On multivariable analysis, PLWH had an independent risk of increased mean log-TBR(max) in AA (coef = 0.12; 95%CI 0.01,0.22; P = .032). HIV infection was independently associated with higher values of interleukin-10 (coef = 0.83; 95%CI 0.34, 1.32; P = .001), interferon-γ (coef. = 0.90; 95%CI 0.32, 1.47; P = .003), and vascular cell adhesion molecule-1 (VCAM-1) (coef. = 0.75; 95%CI: 0.42, 1.08, P < .001). CONCLUSIONS: In patients with high cardiovascular risk, HIV status was an independent predictor of increased TBR(max) in AA. PLWH also had an increased independent risk of IFN-γ, IL-10, and VCAM-1 levels.
Taglieri, Nevio; Bonfiglioli, Rachele; Bon, Isabella; Malosso, Pietro; Corovic, Andrej; Bruno, Matteo; Le, Elizabeth; Granozzi, Bianca; Palmerini, Tullio; Ghetti, Gabriele; Tamburello, Martina; Bruno, Antonio Giulio; Saia, Francesco; Tarkin, Jason M.; Rudd, James H. F.; Calza, Leonardo; Fanti, Stefano; Re, Maria Carla; Galié, Nazzareno
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/852750
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