Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
The microenvironment’s role in mycosis fungoides and sézary syndrome: From progression to therapeutic implications / Pileri A.; Guglielmo A.; Grandi V.; Violetti S.A.; Fanoni D.; Fava P.; Agostinelli C.; Berti E.; Quaglino P.; Pimpinelli N.. - In: CELLS. - ISSN 2073-4409. - STAMPA. - 10:10(2021), pp. 2780.2780-2780.2803. [10.3390/cells10102780]
The microenvironment’s role in mycosis fungoides and sézary syndrome: From progression to therapeutic implications
Pileri A.;Guglielmo A.;Agostinelli C.;
2021
Abstract
Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.| File | Dimensione | Formato | |
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