Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
Pileri A., Guglielmo A., Grandi V., Violetti S.A., Fanoni D., Fava P., et al. (2021). The microenvironment’s role in mycosis fungoides and sézary syndrome: From progression to therapeutic implications. CELLS, 10(10), 2780-2803 [10.3390/cells10102780].
The microenvironment’s role in mycosis fungoides and sézary syndrome: From progression to therapeutic implications
Pileri A.;Guglielmo A.;Agostinelli C.;
2021
Abstract
Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.| File | Dimensione | Formato | |
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