Bacteremia and ventilator-associated pneumonia due to a pan-resistant Klebsiella pneumoniae strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (up to 3 g every 6 h, daily) plus fosfomycin (up to 24 g/daily) that was guided by real-time therapeutic drug monitoring. Clinical pharmacological advice was helpful in maximizing, over time, the pharmacodynamic target attainment of both antibiotics.

Cojutti P.G., Fornaro G., Gatti M., Rinaldi M., Gaibani P., Giannella M., et al. (2022). Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like Klebsiella pneumoniae Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring. INFECTIOUS DISEASE REPORTS, 14(1), 88-92 [10.3390/idr14010010].

Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like Klebsiella pneumoniae Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring

Cojutti P. G.;Fornaro G.;Gatti M.;Rinaldi M.;Gaibani P.;Giannella M.;Pea F.;Viale P.
2022

Abstract

Bacteremia and ventilator-associated pneumonia due to a pan-resistant Klebsiella pneumoniae strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (up to 3 g every 6 h, daily) plus fosfomycin (up to 24 g/daily) that was guided by real-time therapeutic drug monitoring. Clinical pharmacological advice was helpful in maximizing, over time, the pharmacodynamic target attainment of both antibiotics.
2022
Cojutti P.G., Fornaro G., Gatti M., Rinaldi M., Gaibani P., Giannella M., et al. (2022). Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like Klebsiella pneumoniae Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring. INFECTIOUS DISEASE REPORTS, 14(1), 88-92 [10.3390/idr14010010].
Cojutti P.G.; Fornaro G.; Gatti M.; Rinaldi M.; Gaibani P.; Giannella M.; Pea F.; Viale P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/850625
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