Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated. © 2014 Colaneri et al.; licensee BioMed Central Ltd.
Colaneri M., Quarti A., Pozzi M., Gasparini S., Carloni I., De Benedictis F.M. (2014). Management of plastic bronchitis with nebulized tissue plasminogen activator: Another brick in the wall. THE ITALIAN JOURNAL OF PEDIATRICS, 40(1), 1-4 [10.1186/1824-7288-40-18].
Management of plastic bronchitis with nebulized tissue plasminogen activator: Another brick in the wall
Quarti A.Secondo
Conceptualization
;
2014
Abstract
Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated. © 2014 Colaneri et al.; licensee BioMed Central Ltd.File | Dimensione | Formato | |
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