Tocilizumab is a humanised interleukin-6 receptor-inhibiting monoclonal antibody that is currently approved for the treatment of rheumatoid arthritis and other immune-related conditions. Recently, tocilizumab has been investigated as a possible treatment for severe coronavirus-induced disease 2019 (COVID-19). De-spite the lack of direct antiviral effects, tocilizumab could reduce the immune-induced organ damage caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) infection. Until recently, most reports on tocil-izumab for COVID-19 included a limited number of patients, preventing an overall evaluation of its efficacy and safety for this specific condition. Therefore, we reviewed the literature regarding the physiopathological rationale of tocilizumab for COVID-19 and its outcomes. We searched the MEDLINE database with the string “(SARS-CoV-2 OR coronavirus OR COVID-19 OR MERS-cov OR SARS-cov) AND (IL-6 OR interleukin 6 OR tocilizumab)”. While the scientific rationale supporting tocilizumab for COVID-19 is solid, the evidence regarding the outcomes remains controversial. Available data and results from ongoing trials will provide useful information in the event of new COVID-19 outbreaks or future pandemics from different coronaviruses.

Tocilizumab: From rheumatic diseases to covid-19 / Raiteri A.; Piscaglia F.; Granito A.; Tovoli F.. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - ELETTRONICO. - 27:13(2021), pp. 1597-1607. [10.2174/1381612827666210311141512]

Tocilizumab: From rheumatic diseases to covid-19

Raiteri A.;Piscaglia F.;Granito A.;Tovoli F.
2021

Abstract

Tocilizumab is a humanised interleukin-6 receptor-inhibiting monoclonal antibody that is currently approved for the treatment of rheumatoid arthritis and other immune-related conditions. Recently, tocilizumab has been investigated as a possible treatment for severe coronavirus-induced disease 2019 (COVID-19). De-spite the lack of direct antiviral effects, tocilizumab could reduce the immune-induced organ damage caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) infection. Until recently, most reports on tocil-izumab for COVID-19 included a limited number of patients, preventing an overall evaluation of its efficacy and safety for this specific condition. Therefore, we reviewed the literature regarding the physiopathological rationale of tocilizumab for COVID-19 and its outcomes. We searched the MEDLINE database with the string “(SARS-CoV-2 OR coronavirus OR COVID-19 OR MERS-cov OR SARS-cov) AND (IL-6 OR interleukin 6 OR tocilizumab)”. While the scientific rationale supporting tocilizumab for COVID-19 is solid, the evidence regarding the outcomes remains controversial. Available data and results from ongoing trials will provide useful information in the event of new COVID-19 outbreaks or future pandemics from different coronaviruses.
2021
Tocilizumab: From rheumatic diseases to covid-19 / Raiteri A.; Piscaglia F.; Granito A.; Tovoli F.. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - ELETTRONICO. - 27:13(2021), pp. 1597-1607. [10.2174/1381612827666210311141512]
Raiteri A.; Piscaglia F.; Granito A.; Tovoli F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/849591
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