We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.
Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases / Gatti M.; Virgili G.; Cojutti P.G.; Gaibani P.; Conti M.; Sturiale C.; Pea F.; Viale P.. - In: MICROORGANISMS. - ISSN 2076-2607. - ELETTRONICO. - 10:1(2022), pp. 154.1-154.8. [10.3390/microorganisms10010154]
Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
Gatti M.;Virgili G.;Cojutti P. G.;Gaibani P.;Sturiale C.;Pea F.;Viale P.
2022
Abstract
We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.| File | Dimensione | Formato | |
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