The combination of cerium(III) chloride heptahydrate and sodium iodide supported on silica gel is known to promote Michael-type additions. Continuing our work on solvent-free conditions, the CeCl3â7H2O-NaI-SiO2 system catalyzes the addition of a variety of indoles and nitroalkenes, giving 2-indolyl-1-nitroalkane derivatives in good yields. Develop-ment of this method has resulted in a new protocol for the synthesis of 4-substituted â-carbolines.
Efficient Preparation of 2-Indolyl-1-nitroalkane Derivatives Employing Nitroalkenes as Versatile Michael Acceptors: New Practical Linear Approach to Alkyl 9H-b-Carboline-4-carboxylate
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;SAMBRI, LETIZIA;
2005
Abstract
The combination of cerium(III) chloride heptahydrate and sodium iodide supported on silica gel is known to promote Michael-type additions. Continuing our work on solvent-free conditions, the CeCl3â7H2O-NaI-SiO2 system catalyzes the addition of a variety of indoles and nitroalkenes, giving 2-indolyl-1-nitroalkane derivatives in good yields. Develop-ment of this method has resulted in a new protocol for the synthesis of 4-substituted â-carbolines.File in questo prodotto:
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