(Chemical Equation Presented) Conformation analysis and synthesis of 2, a hydrolytically stable mimetic of the tumour antigen, GM3 lactone ganglioside (1 a), is reported (see figure for superimposed images of 1 a and 2). The interaction between 2 and wheat germ agglutinin lectin showed that 2 is a veritable mimetic of a sialyl-containing saccharide. DOPC/DOPE liposomes containing thioether 3 were also prepared and characterized; these could prove to be promising carriers for the production of monoclonal antibodies. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone / Toma L.; Di Cola E.; Ienco A.; Legnani L.; Lunghi C.; Moneti G.; Richichi B.; Ristori S.; Dell'Atti D.; Nativi C.. - In: CHEMBIOCHEM. - ISSN 1439-4227. - ELETTRONICO. - 8:14(2007), pp. 1646-1649. [10.1002/cbic.200700208]

Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone

Lunghi C.
Conceptualization
;
2007

Abstract

(Chemical Equation Presented) Conformation analysis and synthesis of 2, a hydrolytically stable mimetic of the tumour antigen, GM3 lactone ganglioside (1 a), is reported (see figure for superimposed images of 1 a and 2). The interaction between 2 and wheat germ agglutinin lectin showed that 2 is a veritable mimetic of a sialyl-containing saccharide. DOPC/DOPE liposomes containing thioether 3 were also prepared and characterized; these could prove to be promising carriers for the production of monoclonal antibodies. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
2007
Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone / Toma L.; Di Cola E.; Ienco A.; Legnani L.; Lunghi C.; Moneti G.; Richichi B.; Ristori S.; Dell'Atti D.; Nativi C.. - In: CHEMBIOCHEM. - ISSN 1439-4227. - ELETTRONICO. - 8:14(2007), pp. 1646-1649. [10.1002/cbic.200700208]
Toma L.; Di Cola E.; Ienco A.; Legnani L.; Lunghi C.; Moneti G.; Richichi B.; Ristori S.; Dell'Atti D.; Nativi C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/844587
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