An extranodal, PNS T-cell lymphoma, in a 5-year-old, female spayed domestic shorthair cat with a history of progressive peripheral neuropathy was diagnosed. Lymphomatous infiltration aggressed oculomotor nerves and both semilunar ganglia intracranially, the most cranial thoracic spinal roots and ganglia, and intramuscular branches of the cervical muscles. There was also evidence of multifocal leptomeningeal involvement and perivascular cuffing formation within the neuropil of the brain stem and spinal cord. Feline Leukemia proviral DNA was amplified by PCR from neoplastic snap-frozen samples of the semilunar lymphomatous masses. TCR rearrangement detected by means of PCR and Gene Scanning displayed an oligoclonal pattern. Neoplasms affecting feline PNS are uncommon, and malignant lymphomas resulting in PNS complications are rare in both humans and animals. Lymphomas affecting the CNS and PNS in several species (humans, cats and chickens) are often associated with neurotropic and oncoviral infections. This case showed similarities to neurolymphomatosis, a distinct human entity characterized by lymphomatous infiltration of cranial and peripheral nerves and roots.
Extranodal PSN T-cell lymphoma resembling neurolymphomatosis in a cat
MANDRIOLI, LUCIANA;GANDINI, GUALTIERO;MORINI, MARIA;B. Bacci;GENTILINI, FABIO
2009
Abstract
An extranodal, PNS T-cell lymphoma, in a 5-year-old, female spayed domestic shorthair cat with a history of progressive peripheral neuropathy was diagnosed. Lymphomatous infiltration aggressed oculomotor nerves and both semilunar ganglia intracranially, the most cranial thoracic spinal roots and ganglia, and intramuscular branches of the cervical muscles. There was also evidence of multifocal leptomeningeal involvement and perivascular cuffing formation within the neuropil of the brain stem and spinal cord. Feline Leukemia proviral DNA was amplified by PCR from neoplastic snap-frozen samples of the semilunar lymphomatous masses. TCR rearrangement detected by means of PCR and Gene Scanning displayed an oligoclonal pattern. Neoplasms affecting feline PNS are uncommon, and malignant lymphomas resulting in PNS complications are rare in both humans and animals. Lymphomas affecting the CNS and PNS in several species (humans, cats and chickens) are often associated with neurotropic and oncoviral infections. This case showed similarities to neurolymphomatosis, a distinct human entity characterized by lymphomatous infiltration of cranial and peripheral nerves and roots.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
