A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.

Unusual and Unexpected Reactivity of t-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route to t-Butyl Ethers

BARTOLI, GIUSEPPE;BOSCO, MARCELLA;LOCATELLI, MANUELA;MELCHIORRE, PAOLO;SAMBRI, LETIZIA
2005

Abstract

A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.
G. Bartoli; M. Bosco; M. Locatelli; E. Marcantoni; P. Melchiorre; L. Sambri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/8438
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