A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.
G. Bartoli, M. Bosco, M. Locatelli, E. Marcantoni, P. Melchiorre, L. Sambri (2005). Unusual and Unexpected Reactivity of t-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route to t-Butyl Ethers. ORGANIC LETTERS, 7, 427-430 [10.1021/ol047704o].
Unusual and Unexpected Reactivity of t-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route to t-Butyl Ethers
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;LOCATELLI, MANUELA;MELCHIORRE, PAOLO;SAMBRI, LETIZIA
2005
Abstract
A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.File in questo prodotto:
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