A state-of-the-art problem in Computational Systems Biology is to provide suitable tools to model and predict the behaviour of multicellular systems (tissues, embryos) where biological interactions occur both inside and between cells (or compartments in general). Starting from existing computational models and languages such as stochastic pi-calculus, Petri Nets, mobile ambients, and membrane computing, we developed a new computational framework based on (i) a compositional model for biological compartments, and (ii) an enhanced model of chemical rules addressing also biomechanical actions such as substances diffusion across membranes or compartments splitting. We tested a fragment of the framework using a case study based on spatial pattern formation in embryogenesis, where the interplay between cells' internal dynamics and cell-to-cell interactions has a central role

A computational framework for modelling multicellular biochemistry

MONTAGNA, SARA;VIROLI, MIRKO
2009

Abstract

A state-of-the-art problem in Computational Systems Biology is to provide suitable tools to model and predict the behaviour of multicellular systems (tissues, embryos) where biological interactions occur both inside and between cells (or compartments in general). Starting from existing computational models and languages such as stochastic pi-calculus, Petri Nets, mobile ambients, and membrane computing, we developed a new computational framework based on (i) a compositional model for biological compartments, and (ii) an enhanced model of chemical rules addressing also biomechanical actions such as substances diffusion across membranes or compartments splitting. We tested a fragment of the framework using a case study based on spatial pattern formation in embryogenesis, where the interplay between cells' internal dynamics and cell-to-cell interactions has a central role
IEEE Congress on Evolutionary Computation, 2009. CEC '09.
2223
2240
S. Montagna; M. Viroli
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/83858
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 1
social impact