Improving adherence with treatment-resistant hypertension.

Arterial hypertension is the most important risk factor for cardiovascular disease responsible for a large proportion of death and disability-adjusted life-year across the world [1]. Blood pressure control through the administration of first-line classes of antihypertensive drugs has been proven to significantly improve the clinical outcome of hypertension in the overall population and in the subgroups of patients with different degrees of severity of the disease. Suboptimal adherence to antihypertensive medication is one of the major contributors to poor blood pressure control, thus influencing cardiovascular outcomes and health-care costs. Adherence to treatment is a complex phenomenon involving socioeconomic factors, health-care system, the nature of medical conditions as well as therapy- and/or patient-related conditions