High-density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols, alkaloids, carotenoids, phytosterols, and fatty acids, and their effects on macrophage cholesterol efflux and its major pathways. Phytochemicals show the potential to improve the efficiency of each of these pathways. The findings are mainly in preclinical studies, and more clinical research is warranted in this area to develop novel clinical applications.

Soltani S, B.M. (2021). Effects of phytochemicals on macrophage cholesterol efflux capacity: impact on atherosclerosis. PHYTOTHERAPY RESEARCH, 35(6), 2854-2878 [10.1002/ptr.6991].

Effects of phytochemicals on macrophage cholesterol efflux capacity: impact on atherosclerosis

Cicero AFG
Writing – Original Draft Preparation
;
2021

Abstract

High-density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols, alkaloids, carotenoids, phytosterols, and fatty acids, and their effects on macrophage cholesterol efflux and its major pathways. Phytochemicals show the potential to improve the efficiency of each of these pathways. The findings are mainly in preclinical studies, and more clinical research is warranted in this area to develop novel clinical applications.
2021
Soltani S, B.M. (2021). Effects of phytochemicals on macrophage cholesterol efflux capacity: impact on atherosclerosis. PHYTOTHERAPY RESEARCH, 35(6), 2854-2878 [10.1002/ptr.6991].
Soltani S, Boozari M, Cicero AFG, Jamialahmadi T, Sahebkar A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/827479
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