An antagonistic interaction between adenosine A(2A)-and dopamine D2- receptors has been described. Radioligand binding experiments showed a predominant reduction in the number of D2 vs. A(2A)-receptors in the striatum of aged compared to young rats. The A(2A)-receptor-mediated antagonistic modulation of D2-receptor binding remained unchanged in aged animals. In striatal homogenates a significant increase in adenosine and no change in dopamine content was found in aged vs. young rats. These results reveal the existence of an age-dependent imbalance of adenosinee vs. dopamine in favor of adenosine, which involves both presynaptic and postsynaptic mechanisms.
Age-related alteration of the adenosine/dopamine balance in the rat striatum / Popoli P.; Betto P.; Rimondini R.; Reggio R.; Pezzola A.; Ricciarello G.; Fuxe K.; Ferre S.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 795:1-2(1998), pp. 297-300. [10.1016/S0006-8993(98)00356-4]
Age-related alteration of the adenosine/dopamine balance in the rat striatum
Rimondini R.Investigation
;
1998
Abstract
An antagonistic interaction between adenosine A(2A)-and dopamine D2- receptors has been described. Radioligand binding experiments showed a predominant reduction in the number of D2 vs. A(2A)-receptors in the striatum of aged compared to young rats. The A(2A)-receptor-mediated antagonistic modulation of D2-receptor binding remained unchanged in aged animals. In striatal homogenates a significant increase in adenosine and no change in dopamine content was found in aged vs. young rats. These results reveal the existence of an age-dependent imbalance of adenosinee vs. dopamine in favor of adenosine, which involves both presynaptic and postsynaptic mechanisms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.