An antagonistic interaction between adenosine A(2A)-and dopamine D2- receptors has been described. Radioligand binding experiments showed a predominant reduction in the number of D2 vs. A(2A)-receptors in the striatum of aged compared to young rats. The A(2A)-receptor-mediated antagonistic modulation of D2-receptor binding remained unchanged in aged animals. In striatal homogenates a significant increase in adenosine and no change in dopamine content was found in aged vs. young rats. These results reveal the existence of an age-dependent imbalance of adenosinee vs. dopamine in favor of adenosine, which involves both presynaptic and postsynaptic mechanisms.
Popoli P., Betto P., Rimondini R., Reggio R., Pezzola A., Ricciarello G., et al. (1998). Age-related alteration of the adenosine/dopamine balance in the rat striatum. BRAIN RESEARCH, 795(1-2), 297-300 [10.1016/S0006-8993(98)00356-4].
Age-related alteration of the adenosine/dopamine balance in the rat striatum
Rimondini R.Investigation
;
1998
Abstract
An antagonistic interaction between adenosine A(2A)-and dopamine D2- receptors has been described. Radioligand binding experiments showed a predominant reduction in the number of D2 vs. A(2A)-receptors in the striatum of aged compared to young rats. The A(2A)-receptor-mediated antagonistic modulation of D2-receptor binding remained unchanged in aged animals. In striatal homogenates a significant increase in adenosine and no change in dopamine content was found in aged vs. young rats. These results reveal the existence of an age-dependent imbalance of adenosinee vs. dopamine in favor of adenosine, which involves both presynaptic and postsynaptic mechanisms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
