The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activity with similar ED50 values (about 0.2 mg/kg). The ratios between the ED50 values for induction of catalepsy and for antagonizing amphetamine-induced motor activity for CGS 21680, haloperidol, and clozapine were 12,2, and > 30, respectively. Furthermore, CGS 23680 was comparably much stronger than haloperidol or clozapine at antagonizing the motor activity induced by phencyclidine (2 mg/kg subcutaneonsly) than motor activity induced by amphetamine (1 mg/kg i.p.). In conclusion, the present results show a clear "atypical" antipsychotic profile of the adenosine A2A agonist CGS 21680 in animal models. © 1997 American College of Neuropsychopharmacohgy. Published by Elsevier Science Inc.

Adenosine A2A agonists: A potential new type of atypical antipsychotic

Rimondini R.
Primo
Investigation
;
1997

Abstract

The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activity with similar ED50 values (about 0.2 mg/kg). The ratios between the ED50 values for induction of catalepsy and for antagonizing amphetamine-induced motor activity for CGS 21680, haloperidol, and clozapine were 12,2, and > 30, respectively. Furthermore, CGS 23680 was comparably much stronger than haloperidol or clozapine at antagonizing the motor activity induced by phencyclidine (2 mg/kg subcutaneonsly) than motor activity induced by amphetamine (1 mg/kg i.p.). In conclusion, the present results show a clear "atypical" antipsychotic profile of the adenosine A2A agonist CGS 21680 in animal models. © 1997 American College of Neuropsychopharmacohgy. Published by Elsevier Science Inc.
Rimondini R.; Ferre S.; Ogren S.O.; Fuxe K.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/826943
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