Endothelin 1 (ET-1) was unilaterally applied onto the surface of the dorsal frontoparietal cortex of the rat. Cortical blood flow measurements using laser-Doppler flowmetry demonstrated dose-dependent reductions of frontoparietal cortical blood flow. Histological analysis demonstrated dose-related lesions and the time course was followed using MRI. The lesions appear to be associated with a large penumbra area indicated by morphological characteristics. Thus, cortical surface exposure to ET-1 may produce graded lesions of the frontoparietal cortex related to local ischemia.

Fuxe K., Bjelke B., Andbjer B., Grahn H., Rimondini R., Agnati L.F. (1997). Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia. NEUROREPORT, 8(11), 2623-2629 [10.1097/00001756-199707280-00040].

Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia

Rimondini R.
Investigation
;
1997

Abstract

Endothelin 1 (ET-1) was unilaterally applied onto the surface of the dorsal frontoparietal cortex of the rat. Cortical blood flow measurements using laser-Doppler flowmetry demonstrated dose-dependent reductions of frontoparietal cortical blood flow. Histological analysis demonstrated dose-related lesions and the time course was followed using MRI. The lesions appear to be associated with a large penumbra area indicated by morphological characteristics. Thus, cortical surface exposure to ET-1 may produce graded lesions of the frontoparietal cortex related to local ischemia.
1997
Fuxe K., Bjelke B., Andbjer B., Grahn H., Rimondini R., Agnati L.F. (1997). Endothelin-1 induced lesions of the frontoparietal cortex of the rat. A possible model of focal cortical ischemia. NEUROREPORT, 8(11), 2623-2629 [10.1097/00001756-199707280-00040].
Fuxe K.; Bjelke B.; Andbjer B.; Grahn H.; Rimondini R.; Agnati L.F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/826941
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