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EnglishBackground: Little is currently known regarding the cancer preventive potential of cyanidin-3-O-b-glucopyranoside (Cy-g) apart from its antioxidant activity. Methods: We tested Cy-g on Jurkat and HL-60 leukemia cell lines and, to help elucidate whether the effects of Cy-g are specific for cancer cells, also on normal T lymphocytes. Results: Cy-g-induced apoptosis on all three cell systems, and this indicated that Cy-g was not selective towards leukemia cells. Moreover, Cy-g caused HL-60 differentiation. The induction of apoptosis and cytodifferentiation involved different proteins, thus suggesting that Cy-g-induced apoptosis and cytodifferentiation are two distinct events. Conclusions: Although in vitro, our findings indicate that Cy-g possess some interesting biological properties that should encourage further investigation as regards its chemotherapeutic potential.
| Titolo: | In vitro antitumour activity of cyanidin-3-O-beta-glucopyranoside. |
| Autore/i: | FIMOGNARI, CARMELA; Berti F.; Nuesse M.; CANTELLI FORTI, GIORGIO; HRELIA, PATRIZIA |
| Autore/i Unibo: | |
| Anno: | 2005 |
| Rivista: | |
| Abstract: | Background: Little is currently known regarding the cancer preventive potential of cyanidin-3-O-b-glucopyranoside (Cy-g) apart from its antioxidant activity. Methods: We tested Cy-g on Jurkat and HL-60 leukemia cell lines and, to help elucidate whether the effects of Cy-g are specific for cancer cells, also on normal T lymphocytes. Results: Cy-g-induced apoptosis on all three cell systems, and this indicated that Cy-g was not selective towards leukemia cells. Moreover, Cy-g caused HL-60 differentiation. The induction of apoptosis and cytodifferentiation involved different proteins, thus suggesting that Cy-g-induced apoptosis and cytodifferentiation are two distinct events. Conclusions: Although in vitro, our findings indicate that Cy-g possess some interesting biological properties that should encourage further investigation as regards its chemotherapeutic potential. |
| Data prodotto definitivo in UGOV: | 2005-12-13 12:38:03 |
| Data stato definitivo: | 2020-01-30T13:26:01Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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