Repeated but not single administrations of the MAO type B inhibitor (-)-deprenyl (1 μmol/kg s.c. for 21 consecutive days) antagonized the impairment of passive avoidance retention induced by the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (APV), ketamine and dizocilpine (MK801), in rats. In well-washed membranes prepared from the hippocampi of rats repeatedly treated with (-)-deprenyl, the [3H]MK801 specific binding was increased. In contrast, repeated MAO B-selective doses of pargyline or (+)-amphetamine, as well as single injections with (-)-deprenyl failed to change [3H]MK801 binding. It is suggested that the effects of repeated (-)-deprenyl administrations upon NMDA receptors and upon the impairment of acquisition of a passive avoidance task induced by NMDA antagonists could be independent of MAO inhibition. © 1994.

Gandolfi O., Dall'Olio R., Rimondini R., Bongrani S., Valsecchi B. (1994). Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-d-aspartate receptor antagonists. NEUROSCIENCE LETTERS, 165(1-2), 113-116 [10.1016/0304-3940(94)90722-6].

Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-d-aspartate receptor antagonists

Gandolfi O.
Supervision
;
Dall'Olio R.
Co-primo
Writing – Original Draft Preparation
;
Rimondini R.
Secondo
Investigation
;
1994

Abstract

Repeated but not single administrations of the MAO type B inhibitor (-)-deprenyl (1 μmol/kg s.c. for 21 consecutive days) antagonized the impairment of passive avoidance retention induced by the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (APV), ketamine and dizocilpine (MK801), in rats. In well-washed membranes prepared from the hippocampi of rats repeatedly treated with (-)-deprenyl, the [3H]MK801 specific binding was increased. In contrast, repeated MAO B-selective doses of pargyline or (+)-amphetamine, as well as single injections with (-)-deprenyl failed to change [3H]MK801 binding. It is suggested that the effects of repeated (-)-deprenyl administrations upon NMDA receptors and upon the impairment of acquisition of a passive avoidance task induced by NMDA antagonists could be independent of MAO inhibition. © 1994.
1994
Gandolfi O., Dall'Olio R., Rimondini R., Bongrani S., Valsecchi B. (1994). Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-d-aspartate receptor antagonists. NEUROSCIENCE LETTERS, 165(1-2), 113-116 [10.1016/0304-3940(94)90722-6].
Gandolfi O.; Dall'Olio R.; Rimondini R.; Bongrani S.; Valsecchi B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/826893
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