In an extension of our interest in the use of lipases and dehydrogenases2 in organic solvents, we present here our results in the asymmetric reduction of several racemic 2-arylpropanals to their corresponding (2S)-2-aryl-1-propanol derivatives by means of alcohol dehydrogenases in an aqueous–organic medium, involving an efficient biocatalysed DKR process.3 The value of this finding resides in the application of these chiral intermediates to the synthesis of optically active pharmaceutical products of the Profen class (Ibuprofen, Ketoprofen, etc) and fragrances.
Highly efficient asymmetric reduction of arylpropionic aldehydes by Alcohol Dehydrogenases through dynamic kinetic resolution
GIACOMINI, DARIA;EMER, ENRICO;QUINTAVALLA, ARIANNA;GALLETTI, PAOLA
2009
Abstract
In an extension of our interest in the use of lipases and dehydrogenases2 in organic solvents, we present here our results in the asymmetric reduction of several racemic 2-arylpropanals to their corresponding (2S)-2-aryl-1-propanol derivatives by means of alcohol dehydrogenases in an aqueous–organic medium, involving an efficient biocatalysed DKR process.3 The value of this finding resides in the application of these chiral intermediates to the synthesis of optically active pharmaceutical products of the Profen class (Ibuprofen, Ketoprofen, etc) and fragrances.File in questo prodotto:
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