Chloracne, also known as metabolizing acquired dioxin-induced skin hamartomas (MADISH), is a rare disfiguring disease related to dioxin exposure. There is a paucity of literature on the clinical manifestations and pathogenesis of chloracne/MADISH. The aim of this study was to assess the clinical features of this very unusual acneiform eruption and to explore the pathogenesis of the disease. This was a retrospective, observational report study was conducted on five patients belonging to the same nuclear family (father, mother and three children) and a relative (father's brother) living in the same house. Histopathological, immunohistochemical, laboratory and toxicological analyses were performed for all patients. The results suggest that CYP1A1 in human skin is a diagnostic biomarker in chloracne, and was positive for all the patients in our sample. Tetrachlorodibenzo-p-dioxin is the most investigated dioxin responsible for chloracne; however, several other agonists, whether dioxin-like or not, can activate the aryl hydrocarbon receptor. To our knowledge, this Italian case series is the first study to suggest polychlorinated biphenyls as a possible cause of an overstimulation of aryl hydrocarbons causing the consequent acneiform eruption.

Chessa MA, L.P.M. (2021). Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 46(5), 896-900 [10.1111/ced.14617].

Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker.

Chessa MA
Primo
;
La Placa M
Secondo
;
Patrizi A;
2021

Abstract

Chloracne, also known as metabolizing acquired dioxin-induced skin hamartomas (MADISH), is a rare disfiguring disease related to dioxin exposure. There is a paucity of literature on the clinical manifestations and pathogenesis of chloracne/MADISH. The aim of this study was to assess the clinical features of this very unusual acneiform eruption and to explore the pathogenesis of the disease. This was a retrospective, observational report study was conducted on five patients belonging to the same nuclear family (father, mother and three children) and a relative (father's brother) living in the same house. Histopathological, immunohistochemical, laboratory and toxicological analyses were performed for all patients. The results suggest that CYP1A1 in human skin is a diagnostic biomarker in chloracne, and was positive for all the patients in our sample. Tetrachlorodibenzo-p-dioxin is the most investigated dioxin responsible for chloracne; however, several other agonists, whether dioxin-like or not, can activate the aryl hydrocarbon receptor. To our knowledge, this Italian case series is the first study to suggest polychlorinated biphenyls as a possible cause of an overstimulation of aryl hydrocarbons causing the consequent acneiform eruption.
2021
Chessa MA, L.P.M. (2021). Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 46(5), 896-900 [10.1111/ced.14617].
Chessa MA, La Placa M, Patrizi A, Virdi A, Misciali C, Fedrizzi G, Filippi F, Saurat JH, Sorg O, Fontao F, Kaya G, Neri I.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/826518
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