CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by a variety of normal human cell types, including germ cells, immature myeloid cells and mast cells. To evaluate the pattern of CD117 expression in dogs and cats, a polyclonal antibody was applied on paraffin sections from 44 samples of normal tissues and 104 tumors. In both species a strong immunoreactivity was observed in mast cells, interstitial cells of Cajal and in mast cell tumors. Among gastrointestinal mesenchymal neoplasms, five dogs and one cat revealed a strong CD117 expression and this allowed to identify them as gastrointestinal stromal tumors (GISTs).
MORINI M, BETTINI G, PREZIOSI R, MANDRIOLI L (2004). C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 52, 705-708.
C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections
MORINI, MARIA;BETTINI, GIULIANO;PREZIOSI, ROSARIO;MANDRIOLI, LUCIANA
2004
Abstract
CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by a variety of normal human cell types, including germ cells, immature myeloid cells and mast cells. To evaluate the pattern of CD117 expression in dogs and cats, a polyclonal antibody was applied on paraffin sections from 44 samples of normal tissues and 104 tumors. In both species a strong immunoreactivity was observed in mast cells, interstitial cells of Cajal and in mast cell tumors. Among gastrointestinal mesenchymal neoplasms, five dogs and one cat revealed a strong CD117 expression and this allowed to identify them as gastrointestinal stromal tumors (GISTs).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
