CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by a variety of normal human cell types, including germ cells, immature myeloid cells and mast cells. To evaluate the pattern of CD117 expression in dogs and cats, a polyclonal antibody was applied on paraffin sections from 44 samples of normal tissues and 104 tumors. In both species a strong immunoreactivity was observed in mast cells, interstitial cells of Cajal and in mast cell tumors. Among gastrointestinal mesenchymal neoplasms, five dogs and one cat revealed a strong CD117 expression and this allowed to identify them as gastrointestinal stromal tumors (GISTs).

C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections

MORINI, MARIA;BETTINI, GIULIANO;PREZIOSI, ROSARIO;MANDRIOLI, LUCIANA
2004

Abstract

CD117 is a transmembrane tyrosine kinase growth factor receptor expressed by a variety of normal human cell types, including germ cells, immature myeloid cells and mast cells. To evaluate the pattern of CD117 expression in dogs and cats, a polyclonal antibody was applied on paraffin sections from 44 samples of normal tissues and 104 tumors. In both species a strong immunoreactivity was observed in mast cells, interstitial cells of Cajal and in mast cell tumors. Among gastrointestinal mesenchymal neoplasms, five dogs and one cat revealed a strong CD117 expression and this allowed to identify them as gastrointestinal stromal tumors (GISTs).
2004
MORINI M; BETTINI G; PREZIOSI R; MANDRIOLI L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/8245
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