Photothermal therapy has always been a very attractive anti-cancer strategy, drawing a lot of attention thanks to its excellent performance as a non-invasive and pretty safe technique. Lately, nanostructures have become the main characters of the play of cancer therapy due to their ability to absorb near-infrared radiation and efficient light-to-heat conversion. Here we present the synthesis of polyethylene glycol (PEG)-stabilized hybrid ultrasmall (<20 nm) gold–silver nanotriangles (AuAgNTrs) and their application in photothermal therapy. The obtained AuAgNTrs were deeply investigated using high-resolution transmission electron microscopy (HR-TEM). The cell viability assay was performed on U-87 glioblastoma multiforme cell model. Excellent photothermal performance of AuAgNTrs upon irradiation with NIR laser was demonstrated in suspension and in vitro, with >80% cell viability decrease already after 10 min laser irradiation with a laser power P = 3W/cm2 that was proved to be harmless to the control cells. Moreover, a previous cell viability test had shown that the nanoparticles themselves were reasonably biocompatible: without irradiation cell viability remained high. Herein, we show that our hybrid AuAgNTrs exhibit very exciting potential as nanostructures for hyperthermia cancer therapy, mostly due to their easy synthesis protocol, excellent cell compatibility and promising photothermal features.

Synthesis of ultrasmall single-crystal gold–silver alloy nanotriangles and their application in photothermal therapy / Mirko Maturi; Erica Locatelli; Letizia Sambri; Silvia Tortorella; Sašo Šturm; Nina Kostevšek; Mauro Comes Franchini;. - In: NANOMATERIALS. - ISSN 2079-4991. - ELETTRONICO. - 11:4(2021), pp. 912.912-912.922. [10.3390/nano11040912]

Synthesis of ultrasmall single-crystal gold–silver alloy nanotriangles and their application in photothermal therapy

Mirko Maturi;Erica Locatelli;Letizia Sambri;Silvia Tortorella;Mauro Comes Franchini
2021

Abstract

Photothermal therapy has always been a very attractive anti-cancer strategy, drawing a lot of attention thanks to its excellent performance as a non-invasive and pretty safe technique. Lately, nanostructures have become the main characters of the play of cancer therapy due to their ability to absorb near-infrared radiation and efficient light-to-heat conversion. Here we present the synthesis of polyethylene glycol (PEG)-stabilized hybrid ultrasmall (<20 nm) gold–silver nanotriangles (AuAgNTrs) and their application in photothermal therapy. The obtained AuAgNTrs were deeply investigated using high-resolution transmission electron microscopy (HR-TEM). The cell viability assay was performed on U-87 glioblastoma multiforme cell model. Excellent photothermal performance of AuAgNTrs upon irradiation with NIR laser was demonstrated in suspension and in vitro, with >80% cell viability decrease already after 10 min laser irradiation with a laser power P = 3W/cm2 that was proved to be harmless to the control cells. Moreover, a previous cell viability test had shown that the nanoparticles themselves were reasonably biocompatible: without irradiation cell viability remained high. Herein, we show that our hybrid AuAgNTrs exhibit very exciting potential as nanostructures for hyperthermia cancer therapy, mostly due to their easy synthesis protocol, excellent cell compatibility and promising photothermal features.
2021
Synthesis of ultrasmall single-crystal gold–silver alloy nanotriangles and their application in photothermal therapy / Mirko Maturi; Erica Locatelli; Letizia Sambri; Silvia Tortorella; Sašo Šturm; Nina Kostevšek; Mauro Comes Franchini;. - In: NANOMATERIALS. - ISSN 2079-4991. - ELETTRONICO. - 11:4(2021), pp. 912.912-912.922. [10.3390/nano11040912]
Mirko Maturi; Erica Locatelli; Letizia Sambri; Silvia Tortorella; Sašo Šturm; Nina Kostevšek; Mauro Comes Franchini;
File in questo prodotto:
File Dimensione Formato  
Nanomaterials-2021- 11-912-11p.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 3.9 MB
Formato Adobe PDF
3.9 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/823929
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 13
social impact