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EnglishEndothelin (ET)-1 is a potent vasoconstrictor peptide involved in the derangement of respiratory mechanic during endotoxic shock. We measured the kinetic of pulmonary mRNA expression of the key components of the ET system (ET-1, ET-converting enzyme (ECE), ETA and ETB receptors) by Quantitative Real Time RT-PCR in a swine model of endotoxic shock (0, 1, 2, 3, 4 h of continuous LPS infusion - 40μg/Kg/hour; Sham group, 4 h saline infusion). Significative increase of expression levels were observed for ET-1 in LPS treated piglets; the increase started as early as 1 h. On the contrary no significant variations were observed for ECE, ETA and ETB genes. Small gene expression differences observed in respect to our previous results suggest a possible effect of the anesthesiological/surgical protocol on the ET system regulation.
| Titolo: | Cinetica dell’espressione polmonare del sistema endotelina nel modello suino di shock endotossico. | |
| Autore/i: | ZANNONI, AUGUSTA; BERNARDINI, CHIARA; GENTILINI, FABIO; GIUNTI, MASSIMO; BACCI, MARIA LAURA; FORNI, MONICA | |
| Autore/i Unibo: | ||
| Anno: | 2009 | |
| Titolo del libro: | Atti della Società Italiana delle Scienze Veterinarie | |
| Pagina iniziale: | 61 | |
| Pagina finale: | 62 | |
| Abstract: | Endothelin (ET)-1 is a potent vasoconstrictor peptide involved in the derangement of respiratory mechanic during endotoxic shock. We measured the kinetic of pulmonary mRNA expression of the key components of the ET system (ET-1, ET-converting enzyme (ECE), ETA and ETB receptors) by Quantitative Real Time RT-PCR in a swine model of endotoxic shock (0, 1, 2, 3, 4 h of continuous LPS infusion - 40μg/Kg/hour; Sham group, 4 h saline infusion). Significative increase of expression levels were observed for ET-1 in LPS treated piglets; the increase started as early as 1 h. On the contrary no significant variations were observed for ECE, ETA and ETB genes. Small gene expression differences observed in respect to our previous results suggest a possible effect of the anesthesiological/surgical protocol on the ET system regulation. | |
| Data prodotto definitivo in UGOV: | 27-gen-2010 | |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
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