The aim of this study was to evaluate clinicopathological data associated to a racing competition pointing out hemostatic alterations and the potential erythrocyte damage. Thirty-four Standardbred racing horses were studied. Venous blood samples were obtained immediately before the race, and post competition in the following 30 minutes. CBC, Acute Phase Proteins, biochemical and hemostatic parameters including Uric Acid, Haptoglobin, Fibrinogen and D-Dimer, were evaluated. The post exercise data were corrected using an estimation of the plasma volume contraction according to the individual Albumin increase. A plasma volume loss after the race was evidenced (Albumin +6.86%; HCT +25.35%). The post-competition Fibrinogen values were lower than the pre-competition ones (mean -3.71%). Furthermore, D-Dimer concentrations were highly increased after competition (mean +22.79%). These results may suggest that this type of race induces a significant coagulation and fibrinolysis activation. The Haptoglobin concentrations decreased after the competition (mean -8.7%, p<0.01) and the result could be explained with an intravascular hemolysis associated to the race, as reported in human beings.