BACKGROUND: Acute pouchitis, an idiopathic inflammatory condition of the ileal pouch anal anastomosis, is the most frequent complication after proctocolectomy for ulcerative colitis. AIM: To test the hypothesis that sulfasalazine (SASP) might have a synergistic beneficial effect in acute pouchitis, by combining the anti-inflammatory activity of 5-aminosalicylic Acid and the bacteriostatic effect of sulphapyridine. METHODS: Twenty two patients were investigated for acute pouchitis; the Pouchitis Disease Activity Index (PDAI) was calculated and 11 patients with acute pouchitis (PDAI >7) were included in an open study, after obtaining their informed consent. Patients were treated with SASP 500 mg tablets, two tablets three times per day (3000 mg daily), for 2 months. Pouch endoscopy with biopsies was performed at the entry and at the end of the study. RESULTS: According to the PDAI score, 8/11 patients (73%) improved their clinical condition and 7/11 (63%) were in remission at the end of the treatment. At 8 weeks, the median PDAI index decreased from 11.2 +/- 2.3 to 6.6 +/- 4.7 P < 0.01. No adverse events or toxicity were reported and all patients completed the study. CONCLUSIONS: Despite the limitations of the current study, sulfasalazine seems to be a potential treatment for acute pouchitis.

Pilot study: the use of sulfasalazine for the treatment of acute pouchitis / Belluzzi A.; Serrani M.; Roda G.; Bianchi M.L.; Castellani L.; Grazia M.; Rosati G.; Ugolini G.; Roda E.. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - STAMPA. - 15;31(2):(2010), pp. 228-232. [10.1111/j.1365-2036.2009.04163.x]

Pilot study: the use of sulfasalazine for the treatment of acute pouchitis.

BELLUZZI, ANDREA;SERRANI, MARTA;RODA, GIULIA;CASTELLANI, LUCIA;ROSATI, GIANCARLO;UGOLINI, GIAMPAOLO;RODA, ENRICO
2010

Abstract

BACKGROUND: Acute pouchitis, an idiopathic inflammatory condition of the ileal pouch anal anastomosis, is the most frequent complication after proctocolectomy for ulcerative colitis. AIM: To test the hypothesis that sulfasalazine (SASP) might have a synergistic beneficial effect in acute pouchitis, by combining the anti-inflammatory activity of 5-aminosalicylic Acid and the bacteriostatic effect of sulphapyridine. METHODS: Twenty two patients were investigated for acute pouchitis; the Pouchitis Disease Activity Index (PDAI) was calculated and 11 patients with acute pouchitis (PDAI >7) were included in an open study, after obtaining their informed consent. Patients were treated with SASP 500 mg tablets, two tablets three times per day (3000 mg daily), for 2 months. Pouch endoscopy with biopsies was performed at the entry and at the end of the study. RESULTS: According to the PDAI score, 8/11 patients (73%) improved their clinical condition and 7/11 (63%) were in remission at the end of the treatment. At 8 weeks, the median PDAI index decreased from 11.2 +/- 2.3 to 6.6 +/- 4.7 P < 0.01. No adverse events or toxicity were reported and all patients completed the study. CONCLUSIONS: Despite the limitations of the current study, sulfasalazine seems to be a potential treatment for acute pouchitis.
2010
Pilot study: the use of sulfasalazine for the treatment of acute pouchitis / Belluzzi A.; Serrani M.; Roda G.; Bianchi M.L.; Castellani L.; Grazia M.; Rosati G.; Ugolini G.; Roda E.. - In: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. - ISSN 0269-2813. - STAMPA. - 15;31(2):(2010), pp. 228-232. [10.1111/j.1365-2036.2009.04163.x]
Belluzzi A.; Serrani M.; Roda G.; Bianchi M.L.; Castellani L.; Grazia M.; Rosati G.; Ugolini G.; Roda E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/81742
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