In neonatal period, tumours, although very rare, represent an important cause of morbidity and mortality. The prevalence of neoplasms, within the first month after birth, occurs once in every 12,500–27,500 live births, and malignant tumours develop in approximately 40–50% of them. Diagnosis often occur during prenatal screening or during follow-up for a known cancer predispo- sition syndrome; in fact the presence of congeni- tal anomalies, multifocal or bilateral diseases and cancer in close relatives is suggestive for an underlying cancer predisposition syndrome, and genetic counselling and testing should be consid- ered to investigate these possibilities.
Carella, M., Masetti, R., Antonellini, C., Randi, B., Pession, A., Lima, M. (2019). Neuroblastoma in Neonates. Cham : Springer Nature Switzerland AG [10.1007/978-3-319-93534-8_35].
Neuroblastoma in Neonates
Carella, Matteo;Masetti, Riccardo;Pession, Andrea;Lima, Mario
2019
Abstract
In neonatal period, tumours, although very rare, represent an important cause of morbidity and mortality. The prevalence of neoplasms, within the first month after birth, occurs once in every 12,500–27,500 live births, and malignant tumours develop in approximately 40–50% of them. Diagnosis often occur during prenatal screening or during follow-up for a known cancer predispo- sition syndrome; in fact the presence of congeni- tal anomalies, multifocal or bilateral diseases and cancer in close relatives is suggestive for an underlying cancer predisposition syndrome, and genetic counselling and testing should be consid- ered to investigate these possibilities.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
