Humanpapillomavirus(HPV)persistentinfectionsareassociatedwithcervicalcancerandother HPV-related diseases and tumors. Thus, the characterization of long lasting immunity to currently availableHPVvaccinesisimportant. Atotalof149femalesubjectsvaccinatedwithCervarixorGardasil participatedtothestudyandtheywerestratifiedaccordingtoage(10–12-year-oldand16–20-year-old). Humoral immune responses (IgG and neutralizing antibody titers, antibody avidity) and circulating memoryBcellswereanalyzedafteranaverageof4–6yearsfromthethirdimmunization. Thehumoral responses against HPV-16 and HPV-18 (andHPV-6andHPV-11forGardasil) were high in both age groupsandvaccinesuptosixyearsfromthethirddose. However,Cervarixinducedsignificantlyhigher and more persistent antibody responses, while the two vaccines were rather equivalent in inducing memoryBcellsagainstHPV-16andHPV-18. Moreover,thepercentageofsubjectswithvaccine-specific memory B cells was even superior among Gardasil vaccinees and, conversely, Cervarix vaccinated individualswithcirculatingantibodies,butundetectablememoryBcellswerefound. Finally,ahigher proportionofCervarix-vaccinatedsubjectsdisplayedcross-neutralizingresponsesagainstnon-vaccine types HPV-31 and HPV-45. Gardasil and Cervarix may, thus, differe

HPV-Specific Systemic Antibody Responses and Memory B Cells are Independently Maintained up to 6 Years and in a Vaccine-Specific Manner Following Immunization with Cervarix and Gardasil in Adolescent and Young Adult Women in Vaccination Programs in Italy

Lazzarotto T
Data Curation
;
2020

Abstract

Humanpapillomavirus(HPV)persistentinfectionsareassociatedwithcervicalcancerandother HPV-related diseases and tumors. Thus, the characterization of long lasting immunity to currently availableHPVvaccinesisimportant. Atotalof149femalesubjectsvaccinatedwithCervarixorGardasil participatedtothestudyandtheywerestratifiedaccordingtoage(10–12-year-oldand16–20-year-old). Humoral immune responses (IgG and neutralizing antibody titers, antibody avidity) and circulating memoryBcellswereanalyzedafteranaverageof4–6yearsfromthethirdimmunization. Thehumoral responses against HPV-16 and HPV-18 (andHPV-6andHPV-11forGardasil) were high in both age groupsandvaccinesuptosixyearsfromthethirddose. However,Cervarixinducedsignificantlyhigher and more persistent antibody responses, while the two vaccines were rather equivalent in inducing memoryBcellsagainstHPV-16andHPV-18. Moreover,thepercentageofsubjectswithvaccine-specific memory B cells was even superior among Gardasil vaccinees and, conversely, Cervarix vaccinated individualswithcirculatingantibodies,butundetectablememoryBcellswerefound. Finally,ahigher proportionofCervarix-vaccinatedsubjectsdisplayedcross-neutralizingresponsesagainstnon-vaccine types HPV-31 and HPV-45. Gardasil and Cervarix may, thus, differe
2020
Nicoli F, Mantelli B, Gallerani E, Telatin V, Bonazzi I, Marconi P, Gavioli R, Gabrielli L, Lazzarotto T, Barzon L, Palù G, Caputo AA.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/810391
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