AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the nn vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn's disease). Biopsy samples were taken and CD31 expression was assayed immuno-histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/field) compared with NBI-negative areas. CONCLUSION: NBI may allow nn vivo imaging of intestinal angiogenesis in IBD patients. © 2010 Baishideng.
Danese S., Fiorino G., Angelucci E., Vetrano S., Pagano N., Rando G., et al. (2010). Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study. WORLD JOURNAL OF GASTROENTEROLOGY, 16(19), 2396-2400 [10.3748/wjg.v16.i19.2396].
Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study
Pagano N.;
2010
Abstract
AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the nn vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn's disease). Biopsy samples were taken and CD31 expression was assayed immuno-histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/field) compared with NBI-negative areas. CONCLUSION: NBI may allow nn vivo imaging of intestinal angiogenesis in IBD patients. © 2010 Baishideng.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
